BIOMAT Database Logo BIOMAT Database Logo

The effect of hexadimethrine bromide (polybrene) on the infection of the primate retroviruses SSV 1/SSAV 1 and BaEV. 1983

R J Coelen, and D G Jose, and J T May

Polybrene was shown to enhance the adsorption of simian sarcoma virus-simian sarcoma associated virus complex (SSV-1/SSAV-1) and baboon endogenous virus (BaEV) onto cells in culture. A 16- to 18-fold increased adsorption of both viruses occurred at 8 micrograms/ml polybrene within one hour after infection. The polybrene mediated adsorption was found to be inhibited by the addition of tri-sodium citrate to the culture medium, suggesting the involvement of electrostatic forces. This contention was further supported by the demonstration of temperature independence of the polybrene mediated interaction.

UI MeSH Term Description Entries
D011073 Polyamines Amine compounds that consist of carbon chains or rings containing two or more primary amino groups. Polyamine
D002951 Citrates Derivatives of CITRIC ACID.
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D006583 Hexadimethrine Bromide A synthetic polymer which agglutinates red blood cells. It is used as a heparin antagonist. Hexadimethrine,1,5-Dimethyl-1,5-Diazaundecamethylene Polymethobromide,Polybrene,Bromide, Hexadimethrine
D000327 Adsorption The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily. Adsorptions
D012190 Retroviridae Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES). Leukemogenic Viruses,Leukoviruses,Oncornaviruses,Oncovirinae,Oncoviruses,Oncoviruses, Type C,RNA Tumor Viruses,Retroviruses,Type C Oncoviruses,C Oncovirus, Type,C Oncoviruses, Type,Leukemogenic Virus,Leukovirus,Oncornavirus,Oncovirus,Oncovirus, Type C,RNA Tumor Virus,Retrovirus,Tumor Virus, RNA,Tumor Viruses, RNA,Type C Oncovirus,Virus, Leukemogenic,Virus, RNA Tumor,Viruses, Leukemogenic,Viruses, RNA Tumor
D012526 Satellite Viruses Defective viruses which can multiply only by association with a helper virus which complements the defective gene. Satellite viruses may be associated with certain plant viruses, animal viruses, or bacteriophages. They differ from satellite RNA; (RNA, SATELLITE) in that satellite viruses encode their own coat protein. Associated Viruses,Associated Virus,Virus, Associated,Viruses, Associated,Satellite Virus,Virus, Satellite,Viruses, Satellite
D012842 Sarcoma Virus, Woolly Monkey A species of GAMMARETROVIRUS producing tumors in primates. Originally isolated from a fibrosarcoma in a woolly monkey, WMSV is a replication-defective v-onc virus which carries the sis oncogene. In order to propagate, WMSV requires a replication-competent helper virus. Sarcoma Viruses, Simian,Simian Sarcoma Viruses,Wooley monkey sarcoma virus,Woolly Monkey Virus,Sarcoma Virus, Simian,Simian Sarcoma Virus
D013696 Temperature The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms. Temperatures
D019343 Citric Acid A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability. Citrate,Anhydrous Citric Acid,Citric Acid Monohydrate,Citric Acid, Anhydrous,Uralyt U

Related Publications

R J Coelen, and D G Jose, and J T May
[ON INACTIVATION OF THE ANTIHEPARIN EFFECT OF HEXADIMETHRINE BROMIDE (POLYBRENE)].
July 1964, Giornale italiano di chirurgia,
R J Coelen, and D G Jose, and J T May
RENAL TOXICITY OF POLYBRENE, (HEXADIMETHRINE BROMIDE).
May 1965, The Journal of surgical research,
R J Coelen, and D G Jose, and J T May
Further studies on hexadimethrine bromide (polybrene)--an antiheparin agent.
November 1959, Toxicology and applied pharmacology,
R J Coelen, and D G Jose, and J T May
The circulatory effects of hexadimethrine bromide (Polybrene) in dogs.
October 1961, American heart journal,
R J Coelen, and D G Jose, and J T May
V-sis gene (SSV) is expressed transiently and independently of v-gag (SSAV) after infection of fibroblasts with SSV/SSAV.
September 1989, Oncogene,
R J Coelen, and D G Jose, and J T May
INTERACTION OF FACTOR VIII (ANTIHEMOPHILIC GLOBULIN) WITH HEXADIMETHRINE BROMIDE (POLYBRENE).
January 1963, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
R J Coelen, and D G Jose, and J T May
[Manual technic using hexadimethrine bromide (polybrene) for the determination of cryoagglutinins].
August 1988, Sangre,
R J Coelen, and D G Jose, and J T May
Some pharmacologic characteristics of hexadimethrine bromide (polybrene); a new antiheparin agent.
March 1959, Toxicology and applied pharmacology,
R J Coelen, and D G Jose, and J T May
[The production of an experimental eosinophilia in rats by hexadimethrine bromide (Polybrene)].
September 1966, Klinische Wochenschrift,
R J Coelen, and D G Jose, and J T May
The manual hexadimethrine bromide (Polybrene) test. Effects of serum proteins and practical applications.
January 1987, Transfusion,
Copied contents to your clipboard!