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The pharmacokinetic and antibacterial properties of cefotaxime were determined in normal adult volunteers. Single doses of 250, 500, 1,000 and 2,000 mg were evaluated following 5- and 20-min intravenous (i.v.) infusions and intramuscular (i.m.) administration. Cefotaxime was well tolerated and mean peak serum levels exceeded the minimum inhibition concentration (MIC) values for a wide spectrum of potential bacterial pathogens. Approximately 48% of the i.v. doses was excreted renally; average volume of distribution was 30% of body weight and the t 1/2 was about 1 h. Cefotaxime was rapidly absorbed following i.m. injection with maximum serum concentrations occurring at approximately 0.6 h. Serum and urine antibacterial activity reflected the concentration of cefotaxime and MIC of the bacterial pathogens tested.
J F Plouffe, and
R L Perkins, and
R J Fass, and
R B Prior, and
B Bernstein, and
I Ho
September 1980,
The Journal of antimicrobial chemotherapy,
J F Plouffe, and
R L Perkins, and
R J Fass, and
R B Prior, and
B Bernstein, and
I Ho
October 1972,
Antimicrobial agents and chemotherapy,
J F Plouffe, and
R L Perkins, and
R J Fass, and
R B Prior, and
B Bernstein, and
I Ho
January 1982,
Reviews of infectious diseases,
J F Plouffe, and
R L Perkins, and
R J Fass, and
R B Prior, and
B Bernstein, and
I Ho
July 1989,
Journal of chemotherapy (Florence, Italy),
J F Plouffe, and
R L Perkins, and
R J Fass, and
R B Prior, and
B Bernstein, and
I Ho
January 1995,
Diagnostic microbiology and infectious disease,
J F Plouffe, and
R L Perkins, and
R J Fass, and
R B Prior, and
B Bernstein, and
I Ho
June 1984,
Diagnostic microbiology and infectious disease,
J F Plouffe, and
R L Perkins, and
R J Fass, and
R B Prior, and
B Bernstein, and
I Ho
August 1997,
Yao xue xue bao = Acta pharmaceutica Sinica,
J F Plouffe, and
R L Perkins, and
R J Fass, and
R B Prior, and
B Bernstein, and
I Ho
January 1990,
Presse medicale (Paris, France : 1983),
J F Plouffe, and
R L Perkins, and
R J Fass, and
R B Prior, and
B Bernstein, and
I Ho
August 1968,
The American journal of the medical sciences,
J F Plouffe, and
R L Perkins, and
R J Fass, and
R B Prior, and
B Bernstein, and
I Ho
September 1980,
The Journal of antimicrobial chemotherapy,
