-transparent.png){kind=logo}
The ADP,ATP carrier of rat liver mitochondria is specifically inhibited by Meisenheimer-type trinitrophenyl (TNP) derivatives of ADP and ATP. Due to a systematic inhibition study we could show that the TNP-moiety itself, even in the 2', 3'-O-cyclic Meisenheimer complex, revealed no inhibition of mitochondrial ADP,ATP transport. Nucleosidic TNP-compounds are weak inhibitors. Introduction of a phosphate group at the 5'-position, however, enhances the inhibitory power markedly. Our findings point to a synergistic effect of the 5'-phosphate chain and the TNP-moiety. Irreversible inhibition by TNP-nucleotides can be ruled out to the fact that the inhibited ADP,ATP-transport system is fully reactivated by addition of albumin.
E Schlimme, and
K S Boos, and
G Onur, and
G Ponse
January 1978,
European journal of biochemistry,
E Schlimme, and
K S Boos, and
G Onur, and
G Ponse
January 1996,
Society of General Physiologists series,
E Schlimme, and
K S Boos, and
G Onur, and
G Ponse
October 2008,
Biochimica et biophysica acta,
E Schlimme, and
K S Boos, and
G Onur, and
G Ponse
September 1980,
The Journal of membrane biology,
E Schlimme, and
K S Boos, and
G Onur, and
G Ponse
August 1980,
European journal of biochemistry,
E Schlimme, and
K S Boos, and
G Onur, and
G Ponse
July 2000,
International journal of molecular medicine,
E Schlimme, and
K S Boos, and
G Onur, and
G Ponse
September 1978,
Die Naturwissenschaften,
E Schlimme, and
K S Boos, and
G Onur, and
G Ponse
July 1978,
Biochimica et biophysica acta,
E Schlimme, and
K S Boos, and
G Onur, and
G Ponse
May 1973,
Biochimica et biophysica acta,
E Schlimme, and
K S Boos, and
G Onur, and
G Ponse
October 1989,
Journal of photochemistry and photobiology. B, Biology,
