-transparent.png){kind=logo}
The natural sequence of bradykinin (BK) and 55 fragments or analogs of this peptide were perpared via the solid-phase method. The peptides were purified using ion-exchange (O-carboxymethyl(CM) and partition (Sephadex G-25) chromatography. The purity of each peptide was established by paper and thin-layer chromatography, paper electrophoresis, amino acid analysis, and biological assays. The compounds were tested in anesthetized rats (tested in vivo) and in two smooth-muscle preparations (rabbit aorta strip, cat ileum strip) in which BK produces contraction by stimulating specific receptors of different types. Some of the new peptides are interesting in that they either resist pulmonary inactivation, or are more potent than BK itself, or antagonize the myotropic effect of BK in rabbit aorta strips.
W K Park, and
S A St-Pierre, and
J Barabé, and
D Regoli
August 1979,
Canadian journal of biochemistry,
W K Park, and
S A St-Pierre, and
J Barabé, and
D Regoli
April 1981,
Journal of medicinal chemistry,
W K Park, and
S A St-Pierre, and
J Barabé, and
D Regoli
April 1980,
Canadian journal of biochemistry,
W K Park, and
S A St-Pierre, and
J Barabé, and
D Regoli
May 1971,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
W K Park, and
S A St-Pierre, and
J Barabé, and
D Regoli
June 1971,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
W K Park, and
S A St-Pierre, and
J Barabé, and
D Regoli
February 1974,
Canadian journal of biochemistry,
W K Park, and
S A St-Pierre, and
J Barabé, and
D Regoli
January 1969,
Biochemistry,
W K Park, and
S A St-Pierre, and
J Barabé, and
D Regoli
January 1996,
Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity,
W K Park, and
S A St-Pierre, and
J Barabé, and
D Regoli
January 1982,
Journal of medicinal chemistry,
W K Park, and
S A St-Pierre, and
J Barabé, and
D Regoli
June 1972,
Biochemical and biophysical research communications,
