-transparent.png){kind=logo}
Differential uteroglobin induction represents an appropriate model for the molecular analysis of the mechanism by which steroid hormones control gene expression in mammals. We have analyzed the structure and hormonal regulation of a 35 Kb region of genomic DNA in which the uteroglobin gene is located. The complete sequence of 3,700 nucleotides including the uteroglobin gene and its flanking regions has been determined, and the limits of the gene established by S1 nuclease mapping. Several regions containing repeated sequences were mapped by blot hybridization, one of which is located within the large intron in the uteroglobin gene. Analysis of the RNAs extracted from endometrium, lung and liver, after treatment with estrogen and/or progesterone shows that within the 35 Kb region, the uteroglobin gene is the only DNA segment whose transcription into stable RNA is induced by progesterone.
G Suske, and
M Wenz, and
A C Cato, and
M Beato
January 1985,
Anticancer research,
G Suske, and
M Wenz, and
A C Cato, and
M Beato
March 1983,
Endocrinology,
G Suske, and
M Wenz, and
A C Cato, and
M Beato
September 1989,
The Journal of biological chemistry,
G Suske, and
M Wenz, and
A C Cato, and
M Beato
September 2000,
Mammalian genome : official journal of the International Mammalian Genome Society,
G Suske, and
M Wenz, and
A C Cato, and
M Beato
January 1983,
Molekuliarnaia biologiia,
G Suske, and
M Wenz, and
A C Cato, and
M Beato
March 1988,
Nucleic acids research,
G Suske, and
M Wenz, and
A C Cato, and
M Beato
January 1987,
Gene,
G Suske, and
M Wenz, and
A C Cato, and
M Beato
October 1981,
FEBS letters,
G Suske, and
M Wenz, and
A C Cato, and
M Beato
October 1989,
Nucleic acids research,
G Suske, and
M Wenz, and
A C Cato, and
M Beato
February 1996,
Gene,
