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Toxicity to hematopoiesis and lymphocytic function are major considerations in the clinical applicability of antiviral agents. We have examined the toxicities of five antiviral agents showing activity against herpesviruses: vidarabine, acyclovir, (E)-5-(2-bromovinyl)-2'-deoxyuridine, trifluorothymidine, and (S)-9-(2,3-dihydroxypropyl)adenine. The drugs were tested in vitro for inhibition of herpes simplex virus type 1 and human cytomegalovirus replication, effects on marrow progenitor cell growth, effects on lymphocyte responses to mitogen and alloantigen stimulation, and effects on several lymphocyte cytotoxic responses. In general, lymphocyte proliferative responses were inhibited by the various drugs at lower concentrations than were cytotoxic activities. Acyclovir and (E)-5-(2-bromovinyl)-2'-deoxyuridine were the least toxic drugs tested, with antiviral indices exceeding 10,000. Vidarabine and trifluorothymidine were more toxic, with antiviral indices generally between 10 and 100. (S)-9-(2,3-dihydroxypropyl)-adenine was the most toxic, with several antiviral indices between 1 and 10.
J R Wingard, and
A D Hess, and
R K Stuart, and
R Saral, and
W H Burns
February 2014,
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology,
J R Wingard, and
A D Hess, and
R K Stuart, and
R Saral, and
W H Burns
January 1994,
Biological trace element research,
J R Wingard, and
A D Hess, and
R K Stuart, and
R Saral, and
W H Burns
February 2004,
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine,
J R Wingard, and
A D Hess, and
R K Stuart, and
R Saral, and
W H Burns
January 1986,
Transactions of the Royal Society of Tropical Medicine and Hygiene,
J R Wingard, and
A D Hess, and
R K Stuart, and
R Saral, and
W H Burns
September 1983,
Journal of the Reticuloendothelial Society,
J R Wingard, and
A D Hess, and
R K Stuart, and
R Saral, and
W H Burns
February 1996,
Biulleten' eksperimental'noi biologii i meditsiny,
J R Wingard, and
A D Hess, and
R K Stuart, and
R Saral, and
W H Burns
January 1986,
Transactions of the Royal Society of Tropical Medicine and Hygiene,
J R Wingard, and
A D Hess, and
R K Stuart, and
R Saral, and
W H Burns
January 1986,
European journal of clinical pharmacology,
J R Wingard, and
A D Hess, and
R K Stuart, and
R Saral, and
W H Burns
August 1982,
Blood,
J R Wingard, and
A D Hess, and
R K Stuart, and
R Saral, and
W H Burns
January 2000,
Stem cells (Dayton, Ohio),
