Biomaterial Database

[Cation-anion selectivity and conductivity of the channels formed by black widow spider whole venom in lipid bilayer]. 1983

O V Krasil'nikov, and V I Ternovskiĭ, and B A Tashmukhamedov

It is established that BWSV (black widow spider venom) is capable of forming ion channels in lipid bilayer (BPhM). This effect is minimal upon pH value close to 5.0 and is increased either upon oxidation or alkalization of the medium. The amplitudes of the channels are monotonously decreased upon the reduction of pH with simultaneous narrowing of their dispersion. The degree of the change of BPhM conductivity by concentration of BWSV is close to 2 at different pH. Apparently the absorption of the active component of venom on bilayer surface is accompanied by doubling of the degree of its aggregation. Almost ideal cation selectivity of BWSV channels (pH 7.5) is significantly decreased upon the increase in ionic strength. Ionic channel is thought to be a zone of interaction of lipid domains. Possible structure of such a channel is discussed.

UI	MeSH Term	Description	Entries
D007473	Ion Channels	Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.	Membrane Channels,Ion Channel,Ionic Channel,Ionic Channels,Membrane Channel,Channel, Ion,Channel, Ionic,Channel, Membrane,Channels, Ion,Channels, Ionic,Channels, Membrane
D008051	Lipid Bilayers	Layers of lipid molecules which are two molecules thick. Bilayer systems are frequently studied as models of biological membranes.	Bilayers, Lipid,Bilayer, Lipid,Lipid Bilayer
D001740	Black Widow Spider	A venomous New World spider with an hourglass-shaped red mark on the abdomen.	Lactrodectus schuchii,Latrodectus mactans,Southern Black Widow Spider,Black Widow Spiders,Spider, Black Widow,Widow Spider, Black
D002412	Cations	Positively charged atoms, radicals or groups of atoms which travel to the cathode or negative pole during electrolysis.	Cation
D004553	Electric Conductivity	The ability of a substrate to allow the passage of ELECTRONS.	Electrical Conductivity,Conductivity, Electric,Conductivity, Electrical
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000838	Anions	Negatively charged atoms, radicals or groups of atoms which travel to the anode or positive pole during electrolysis.	Anion
D001180	Arthropod Venoms	Venoms from animals of the phylum ARTHROPODA. Those most investigated are from SCORPIONS and SPIDERS of the class Arachnidae and from ant, bee, and wasp families of the INSECTA order HYMENOPTERA. The venoms contain protein toxins, enzymes, and other bioactive substances and may be lethal to man.	Arachnid Toxin,Arachnid Toxins,Arachnid Venoms,Hymenoptera Venom,Hymenoptera Venoms,Insect Venom,Insect Venoms,Arachnid Venom,Arthropod Venom,Toxin, Arachnid,Toxins, Arachnid,Venom, Arachnid,Venom, Arthropod,Venom, Hymenoptera,Venom, Insect,Venoms, Arachnid,Venoms, Arthropod,Venoms, Hymenoptera,Venoms, Insect
D013111	Spider Venoms	Venoms of arthropods of the order Araneida of the ARACHNIDA. The venoms usually contain several protein fractions, including ENZYMES, hemolytic, neurolytic, and other TOXINS, BIOLOGICAL.	Araneid Venoms,Spider Toxin,Spider Toxins,Tarantula Toxin,Tarantula Toxins,Tarantula Venom,Araneid Venom,Spider Venom,Tarantula Venoms,Toxin, Spider,Toxin, Tarantula,Toxins, Spider,Toxins, Tarantula,Venom, Araneid,Venom, Spider,Venom, Tarantula,Venoms, Araneid,Venoms, Spider,Venoms, Tarantula