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The disposition and bioavailability of ceftriaxone, a novel cephalosporin, was studied in 7 healthy volunteers after a single 1.5-gram intramuscular administration in comparison with the same dose given by the intravenous route. The plasma levels were measured by means of a high-performance liquid chromatography method up to 48 h after administration. Comparable areas under plasma concentration-time curve (AUC) and biological half-life were obtained proving that ceftriaxone, if assessed by conventional methods, is completely bioavailable when given by the intramuscular route. However, taking into account its nonlinear pharmacokinetics it becomes obvious that direct comparison of AUC values generally leads to a certain overestimation of bioavailability after extravascular administration. This aspect is briefly discussed.
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C M Baroni, and
G Crotti, and
F Mineo, and
U Butturini, and
V Ascalone, and
M Cisternino
October 2002,
British journal of clinical pharmacology,
R Delsignore, and
C M Baroni, and
G Crotti, and
F Mineo, and
U Butturini, and
V Ascalone, and
M Cisternino
January 1984,
Arzneimittel-Forschung,
R Delsignore, and
C M Baroni, and
G Crotti, and
F Mineo, and
U Butturini, and
V Ascalone, and
M Cisternino
January 1993,
Arzneimittel-Forschung,
R Delsignore, and
C M Baroni, and
G Crotti, and
F Mineo, and
U Butturini, and
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M Cisternino
December 1987,
Arzneimittel-Forschung,
R Delsignore, and
C M Baroni, and
G Crotti, and
F Mineo, and
U Butturini, and
V Ascalone, and
M Cisternino
February 2008,
British journal of clinical pharmacology,
R Delsignore, and
C M Baroni, and
G Crotti, and
F Mineo, and
U Butturini, and
V Ascalone, and
M Cisternino
May 1984,
Chemical & pharmaceutical bulletin,
R Delsignore, and
C M Baroni, and
G Crotti, and
F Mineo, and
U Butturini, and
V Ascalone, and
M Cisternino
September 1994,
Arzneimittel-Forschung,
R Delsignore, and
C M Baroni, and
G Crotti, and
F Mineo, and
U Butturini, and
V Ascalone, and
M Cisternino
January 1986,
Giornale di stomatologia e di ortognatodonzia,
R Delsignore, and
C M Baroni, and
G Crotti, and
F Mineo, and
U Butturini, and
V Ascalone, and
M Cisternino
August 2018,
Molecules (Basel, Switzerland),
R Delsignore, and
C M Baroni, and
G Crotti, and
F Mineo, and
U Butturini, and
V Ascalone, and
M Cisternino
January 1994,
European journal of clinical pharmacology,
