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Eight healthy volunteers were sequentially fed a control diet, a charcoal-broiled beef--containing diet, and the control diet a second time. The mean plasma half-lives (t1/2) of antipyrine and theophylline were each decreased by 22% after the subjects were fed the charcoal-broiled beed--containing diet. The main plasma t1/2s for these drugs returned to control values when the subjects were fed the control diet for a second time. Considerable individuality occurred in the responsiveness of the subjects to the charcoal-broiled beef--containing diet. The decreases in antipyrine plasma t1/2s among the 8 subjects ranged from 5% to 39%, and the decreases in theophylling t1/2s ranged from 0% to 42%.
A Kappas, and
A P Alvares, and
K E Anderson, and
E J Pantuck, and
C B Pantuck, and
R Chang, and
A H Conney
September 1983,
Clinical pharmacology and therapeutics,
A Kappas, and
A P Alvares, and
K E Anderson, and
E J Pantuck, and
C B Pantuck, and
R Chang, and
A H Conney
February 1975,
Science (New York, N.Y.),
A Kappas, and
A P Alvares, and
K E Anderson, and
E J Pantuck, and
C B Pantuck, and
R Chang, and
A H Conney
August 1971,
Biochemical pharmacology,
A Kappas, and
A P Alvares, and
K E Anderson, and
E J Pantuck, and
C B Pantuck, and
R Chang, and
A H Conney
May 1987,
Clinical pharmacology and therapeutics,
A Kappas, and
A P Alvares, and
K E Anderson, and
E J Pantuck, and
C B Pantuck, and
R Chang, and
A H Conney
March 1990,
Biopharmaceutics & drug disposition,
A Kappas, and
A P Alvares, and
K E Anderson, and
E J Pantuck, and
C B Pantuck, and
R Chang, and
A H Conney
June 1984,
Clinical pharmacology and therapeutics,
A Kappas, and
A P Alvares, and
K E Anderson, and
E J Pantuck, and
C B Pantuck, and
R Chang, and
A H Conney
June 1979,
Food and cosmetics toxicology,
A Kappas, and
A P Alvares, and
K E Anderson, and
E J Pantuck, and
C B Pantuck, and
R Chang, and
A H Conney
July 1990,
Carcinogenesis,
A Kappas, and
A P Alvares, and
K E Anderson, and
E J Pantuck, and
C B Pantuck, and
R Chang, and
A H Conney
November 1983,
British journal of clinical pharmacology,
A Kappas, and
A P Alvares, and
K E Anderson, and
E J Pantuck, and
C B Pantuck, and
R Chang, and
A H Conney
December 1984,
Clinical pharmacology and therapeutics,
