-transparent.png){kind=logo}
The treatment of transformed rat cells with micromolar amounts of 5'deoxy 5'methyl thioadenosine induces rapid effects on the rate of methylation of DNA concomitantly with alterations of intracellular pools of S-adenosyl methionine and S-adenosyl homocysteine. Pulse chase labelling experiments indicate that 5'deoxy 5'methylthioadenosine does not inhibit the degradation of S-adenosyl homocysteine but inhibits the consumption of S-adenosyl methionine. In vitro transmethylation assays performed with heterologous DNA show that low doses of the thioethernucleoside do not significantly affect the DNA methyltransferase activity of cellular extracts. The biological role of 5'deoxy 5'methylthioadenosine, a natural molecule formed during the synthesis of polyamines is discussed.
R Dante, and
M Arnaud, and
A Niveleau
July 1986,
FEBS letters,
R Dante, and
M Arnaud, and
A Niveleau
January 2001,
Nucleosides, nucleotides & nucleic acids,
R Dante, and
M Arnaud, and
A Niveleau
May 1981,
Biochemical and biophysical research communications,
R Dante, and
M Arnaud, and
A Niveleau
January 2014,
PloS one,
R Dante, and
M Arnaud, and
A Niveleau
October 1983,
Cancer research,
R Dante, and
M Arnaud, and
A Niveleau
January 1989,
General pharmacology,
R Dante, and
M Arnaud, and
A Niveleau
January 1986,
Advances in experimental medicine and biology,
R Dante, and
M Arnaud, and
A Niveleau
June 1983,
Biochemical pharmacology,
R Dante, and
M Arnaud, and
A Niveleau
January 2001,
Nucleosides, nucleotides & nucleic acids,
R Dante, and
M Arnaud, and
A Niveleau
January 1991,
Anticancer research,
