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In a prospective study, 50 women patients were given 2 g Ceftriaxon (Rocephin) as a short infusion before performing hysterectomy. A control group of 50 patients remained without any antibiotic treatment. In 31 patients, the concentration of Ceftriaxon in the serum and tissue was determined at the time the uterus was removed. Due to the long half-life of Ceftriaxon (8 hours), high serum and tissue levels were found for a period of many hours. After 4-5 hours, the serum level was still 100 micrograms/ml, whereas the concentration in the endometrium, myometrium and in the salpinges were 21 micrograms/g, 24 micrograms/g and 31 micrograms/g, respectively. Due to these long-lasting serum and tissue levels, the protective effect against infections was also very high. 15 infections in the control group are contrasted by one infection only in the treated group. The efficacy of the prophylaxis is objectively assessed by measuring the temperature curve and by determining the number and the spectrum of the postoperatively isolated germs. The germs isolated in the treated group are exclusively such germs which are resistant to Ceftriaxon (enterococci) or which are only moderately sensitive to Ceftriaxon, such as Bacteroides.
E E Petersen, and
F D Daschner, and
K Pelz, and
G Birmelin, and
H G Hillemanns
February 1978,
The Australian & New Zealand journal of obstetrics & gynaecology,
E E Petersen, and
F D Daschner, and
K Pelz, and
G Birmelin, and
H G Hillemanns
January 1990,
Enfermedades infecciosas y microbiologia clinica,
E E Petersen, and
F D Daschner, and
K Pelz, and
G Birmelin, and
H G Hillemanns
June 1987,
Obstetrics and gynecology,
E E Petersen, and
F D Daschner, and
K Pelz, and
G Birmelin, and
H G Hillemanns
January 1980,
Duodecim; laaketieteellinen aikakauskirja,
E E Petersen, and
F D Daschner, and
K Pelz, and
G Birmelin, and
H G Hillemanns
June 2007,
Archives of surgery (Chicago, Ill. : 1960),
E E Petersen, and
F D Daschner, and
K Pelz, and
G Birmelin, and
H G Hillemanns
May 2006,
International journal of oral and maxillofacial surgery,
E E Petersen, and
F D Daschner, and
K Pelz, and
G Birmelin, and
H G Hillemanns
June 2013,
The journal of pain,
E E Petersen, and
F D Daschner, and
K Pelz, and
G Birmelin, and
H G Hillemanns
January 1989,
Annales de chirurgie,
E E Petersen, and
F D Daschner, and
K Pelz, and
G Birmelin, and
H G Hillemanns
November 2020,
Journal of infection in developing countries,
E E Petersen, and
F D Daschner, and
K Pelz, and
G Birmelin, and
H G Hillemanns
January 1987,
Minerva urologica e nefrologica = The Italian journal of urology and nephrology,
