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We examined the ability of deleted versions of the herpes simplex virus type 1 thymidine kinase gene, present in biochemically transformed mouse cells, to be induced in trans to a higher level of expression by superinfecting herpes simplex virus immediate early gene products. The results demonstrate that sequences mapping between -200 and -80 and between -70 and -12 are required for induction. As these regions are largely coincident with the previously identified thymidine kinase gene promoter, the results suggest that herpes simplex virus immediate early gene products or their metabolic product activate thymidine kinase expression by acting at the promoter region to increase the rate of transcription.
J R Smiley, and
H Swan, and
M M Pater, and
A Pater, and
M E Halpern
November 1979,
The Journal of general virology,
J R Smiley, and
H Swan, and
M M Pater, and
A Pater, and
M E Halpern
January 1978,
IARC scientific publications,
J R Smiley, and
H Swan, and
M M Pater, and
A Pater, and
M E Halpern
November 1980,
Somatic cell genetics,
J R Smiley, and
H Swan, and
M M Pater, and
A Pater, and
M E Halpern
January 1980,
Journal of virology,
J R Smiley, and
H Swan, and
M M Pater, and
A Pater, and
M E Halpern
January 1976,
Bulletin du cancer,
J R Smiley, and
H Swan, and
M M Pater, and
A Pater, and
M E Halpern
June 1987,
FEBS letters,
J R Smiley, and
H Swan, and
M M Pater, and
A Pater, and
M E Halpern
January 1978,
IARC scientific publications,
J R Smiley, and
H Swan, and
M M Pater, and
A Pater, and
M E Halpern
April 1975,
Somatic cell genetics,
J R Smiley, and
H Swan, and
M M Pater, and
A Pater, and
M E Halpern
December 1982,
Cell,
J R Smiley, and
H Swan, and
M M Pater, and
A Pater, and
M E Halpern
January 1984,
The Journal of general virology,
