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The effects of secretin on glucose output and cyclic AMP from the isolated perfused rat liver were investigated. Secretin 0.1 U/ml increased cyclic AMP in the effluent without an increase in glucose output. Glucose output induced by epinephrine 10(-8)M was not affected by secretin 0.1 U/ml administered simultaneously, whereas the increase in cyclic AMP produced by secretin 0.1 U/ml was inhibited by epinephrine 10(-8)M. The increase in cyclic AMP produced by glucagon 10(-10)M was not affected by epinephrine 10(-8)M. These results suggest that secretin does not affect glycogenolysis in the liver and secretin activates adenylate cyclase through a different receptor from glucagon in the liver.
K Yamatani, and
N Sato, and
K Takahashi, and
M Hara, and
H Sasaki
May 1973,
Biochemical and biophysical research communications,
K Yamatani, and
N Sato, and
K Takahashi, and
M Hara, and
H Sasaki
August 1976,
Archives of biochemistry and biophysics,
K Yamatani, and
N Sato, and
K Takahashi, and
M Hara, and
H Sasaki
April 1976,
Biochemical pharmacology,
K Yamatani, and
N Sato, and
K Takahashi, and
M Hara, and
H Sasaki
November 1977,
The Journal of biological chemistry,
K Yamatani, and
N Sato, and
K Takahashi, and
M Hara, and
H Sasaki
November 1973,
Research communications in chemical pathology and pharmacology,
K Yamatani, and
N Sato, and
K Takahashi, and
M Hara, and
H Sasaki
May 1972,
The American journal of physiology,
K Yamatani, and
N Sato, and
K Takahashi, and
M Hara, and
H Sasaki
February 1971,
Journal of ultrastructure research,
K Yamatani, and
N Sato, and
K Takahashi, and
M Hara, and
H Sasaki
January 1977,
Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie,
K Yamatani, and
N Sato, and
K Takahashi, and
M Hara, and
H Sasaki
September 1974,
Endocrinology,
K Yamatani, and
N Sato, and
K Takahashi, and
M Hara, and
H Sasaki
May 1958,
The American journal of physiology,
