-transparent.png){kind=logo}
Theophylline reversibly inhibits E rosette formation by a portion of human circulating T lymphocytes. We investigated the effect of theophylline on E rosette formation and intracellular content of cyclic nucleotides (cAMP, cGMP). When the amine is added to 15 human healthy donors' lymphocytes either before or after 24 hours of culture at 37 degrees C, in absence of mitogens, a portion of theophylline-sensitive T cells spontaneously becomes theophylline-resistant after 24 hours of culture. While the intracellular content of cAMP does not significantly vary, the ability of theophylline to induce an increase of cAMP appears to be impaired after 24 hours of culture. The possible correlation between theophylline resistance and impaired turnover of cAMP in the cultured lymphocytes is discussed.
G F Ciboddo, and
G Gromo, and
M C Barbieri, and
F Crosti, and
M E Ferrero, and
C Besana, and
C Rugarli
October 1977,
Journal of immunology (Baltimore, Md. : 1950),
G F Ciboddo, and
G Gromo, and
M C Barbieri, and
F Crosti, and
M E Ferrero, and
C Besana, and
C Rugarli
January 1985,
Journal of immunopharmacology,
G F Ciboddo, and
G Gromo, and
M C Barbieri, and
F Crosti, and
M E Ferrero, and
C Besana, and
C Rugarli
March 1987,
Immunology,
G F Ciboddo, and
G Gromo, and
M C Barbieri, and
F Crosti, and
M E Ferrero, and
C Besana, and
C Rugarli
June 1971,
Japanese journal of medical science & biology,
G F Ciboddo, and
G Gromo, and
M C Barbieri, and
F Crosti, and
M E Ferrero, and
C Besana, and
C Rugarli
June 2001,
Genetika,
G F Ciboddo, and
G Gromo, and
M C Barbieri, and
F Crosti, and
M E Ferrero, and
C Besana, and
C Rugarli
January 1977,
Eksperimentalna meditsina i morfologiia,
G F Ciboddo, and
G Gromo, and
M C Barbieri, and
F Crosti, and
M E Ferrero, and
C Besana, and
C Rugarli
April 1992,
Mutation research,
G F Ciboddo, and
G Gromo, and
M C Barbieri, and
F Crosti, and
M E Ferrero, and
C Besana, and
C Rugarli
September 1984,
Clinical and experimental immunology,
G F Ciboddo, and
G Gromo, and
M C Barbieri, and
F Crosti, and
M E Ferrero, and
C Besana, and
C Rugarli
January 1988,
Clinical immunology and immunopathology,
G F Ciboddo, and
G Gromo, and
M C Barbieri, and
F Crosti, and
M E Ferrero, and
C Besana, and
C Rugarli
December 1979,
Clinical and experimental immunology,
