-transparent.png){kind=logo}
Intravenous injections of 50 micrograms corticotropin-releasing factor (CRF) to four normal men at 0900 and 2300 h were followed by significant plasma ACTH and cortisol elevations, without changes in GH and PRL concentrations. The responses were more easily assessed late in the evening than in the morning, when they were superimposed upon the spontaneous hormonal variations. The initial hormonal response was always followed by a period of decreased hormonal values compared to control patterns. The normal pituitary-adrenal response to CRF was blunted or abolished by prior administration of dexamethasone. These data suggest that exogenous administration or CRF-induced endogenous production of glucocorticoids modulates the sensitivity of corticotropic cells to the action of CRF. Since normal ACTH and cortisol secretory episodes are likely to obscure the effects of CRF, stimulation tests for clinical purposes should be performed during the quiescent period, i.e. late in the evening.
G Copinschi, and
M Beyloos, and
D Bosson, and
D Desir, and
J Goldstein, and
C Robyn, and
P Linkowski, and
J Mendlewicz, and
J R Franckson
May 1989,
The Journal of clinical endocrinology and metabolism,
G Copinschi, and
M Beyloos, and
D Bosson, and
D Desir, and
J Goldstein, and
C Robyn, and
P Linkowski, and
J Mendlewicz, and
J R Franckson
December 1984,
The Journal of clinical endocrinology and metabolism,
G Copinschi, and
M Beyloos, and
D Bosson, and
D Desir, and
J Goldstein, and
C Robyn, and
P Linkowski, and
J Mendlewicz, and
J R Franckson
July 1987,
Pediatric research,
G Copinschi, and
M Beyloos, and
D Bosson, and
D Desir, and
J Goldstein, and
C Robyn, and
P Linkowski, and
J Mendlewicz, and
J R Franckson
January 1984,
The Journal of clinical endocrinology and metabolism,
G Copinschi, and
M Beyloos, and
D Bosson, and
D Desir, and
J Goldstein, and
C Robyn, and
P Linkowski, and
J Mendlewicz, and
J R Franckson
March 1983,
The Journal of clinical investigation,
G Copinschi, and
M Beyloos, and
D Bosson, and
D Desir, and
J Goldstein, and
C Robyn, and
P Linkowski, and
J Mendlewicz, and
J R Franckson
October 1984,
The New England journal of medicine,
G Copinschi, and
M Beyloos, and
D Bosson, and
D Desir, and
J Goldstein, and
C Robyn, and
P Linkowski, and
J Mendlewicz, and
J R Franckson
June 1997,
The Journal of clinical endocrinology and metabolism,
G Copinschi, and
M Beyloos, and
D Bosson, and
D Desir, and
J Goldstein, and
C Robyn, and
P Linkowski, and
J Mendlewicz, and
J R Franckson
January 1989,
Hormone research,
G Copinschi, and
M Beyloos, and
D Bosson, and
D Desir, and
J Goldstein, and
C Robyn, and
P Linkowski, and
J Mendlewicz, and
J R Franckson
November 1989,
Endocrine reviews,
G Copinschi, and
M Beyloos, and
D Bosson, and
D Desir, and
J Goldstein, and
C Robyn, and
P Linkowski, and
J Mendlewicz, and
J R Franckson
June 1984,
Acta medica Okayama,
