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A patient with Cushing's disease was unsuccessfully treated by pituitary surgery and external pituitary irradiation. One year later sodium valproate treatment induced a remission and finally hypocorticism developed. After drug withdrawal hypercoticism recurred. Treatment with cyproheptadine again induced hypocorticism necessitating corticosteroid substitution therapy. Biochemical characteristics of this patient included responsiveness to bromocriptine and cyproheptadine in acute tests. The study demonstrates that sodium valproate and cyproheptadine may both be effective independently in the treatment of the same patient with Cushing's disease. It is proposed that the disease is due to an ACTH producing tumour of pituitary intermediate lobe origin.
H P Koppeschaar, and
R J Croughs, and
J H Thijssen, and
F Schwarz
January 1991,
Revista clinica espanola,
H P Koppeschaar, and
R J Croughs, and
J H Thijssen, and
F Schwarz
October 1975,
The New England journal of medicine,
H P Koppeschaar, and
R J Croughs, and
J H Thijssen, and
F Schwarz
July 1984,
Lancet (London, England),
H P Koppeschaar, and
R J Croughs, and
J H Thijssen, and
F Schwarz
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H P Koppeschaar, and
R J Croughs, and
J H Thijssen, and
F Schwarz
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H P Koppeschaar, and
R J Croughs, and
J H Thijssen, and
F Schwarz
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H P Koppeschaar, and
R J Croughs, and
J H Thijssen, and
F Schwarz
May 1977,
Lancet (London, England),
H P Koppeschaar, and
R J Croughs, and
J H Thijssen, and
F Schwarz
June 1977,
Lancet (London, England),
H P Koppeschaar, and
R J Croughs, and
J H Thijssen, and
F Schwarz
March 1983,
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H P Koppeschaar, and
R J Croughs, and
J H Thijssen, and
F Schwarz
September 1984,
Lancet (London, England),
