-transparent.png){kind=logo}
Blast cells from untreated cases of acute leukemia were examined for expression of terminal transferase enzyme (TdT) by immunofluorescence and for myeloid lineage commitment as demonstrated by the presence of myeloperoxidase enzyme at the ultrastructural level. In three cases, an overlapping expression of the "lymphoid-specific" marker TdT was found on peroxidase-positive myeloblasts. These results indicate either the clonal expansion of a rare TdT-positive myeloid precursor or inappropriate expression of TdT by malignant myeloblasts, and further illustrate that TdT expression must be interpreted with caution when distinguishing between lymphoid and myeloid leukemias.
Related Publications
K F Bradstock, and
J Hewson, and
A Kerr, and
A Kabral, and
C H Lee, and
W G Hughes
September 1977,
The New England journal of medicine,
K F Bradstock, and
J Hewson, and
A Kerr, and
A Kabral, and
C H Lee, and
W G Hughes
August 2006,
Leukemia research,
K F Bradstock, and
J Hewson, and
A Kerr, and
A Kabral, and
C H Lee, and
W G Hughes
October 1981,
Human pathology,
K F Bradstock, and
J Hewson, and
A Kerr, and
A Kabral, and
C H Lee, and
W G Hughes
January 1980,
American journal of clinical pathology,
K F Bradstock, and
J Hewson, and
A Kerr, and
A Kabral, and
C H Lee, and
W G Hughes
June 1978,
Haematologica,
K F Bradstock, and
J Hewson, and
A Kerr, and
A Kabral, and
C H Lee, and
W G Hughes
June 1994,
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc,
K F Bradstock, and
J Hewson, and
A Kerr, and
A Kabral, and
C H Lee, and
W G Hughes
March 1995,
Nihon rinsho. Japanese journal of clinical medicine,
K F Bradstock, and
J Hewson, and
A Kerr, and
A Kabral, and
C H Lee, and
W G Hughes
December 2004,
Nihon rinsho. Japanese journal of clinical medicine,
K F Bradstock, and
J Hewson, and
A Kerr, and
A Kabral, and
C H Lee, and
W G Hughes
September 1999,
Nihon rinsho. Japanese journal of clinical medicine,
K F Bradstock, and
J Hewson, and
A Kerr, and
A Kabral, and
C H Lee, and
W G Hughes
September 1985,
The Journal of biological chemistry,
