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A highly reproducible model of fulminant hepatic failure was developed by administering intravenously the selective hepatotoxin galactosamine hydrochloride (4.25 mmoles per kg) to genetically uniform rabbits. The great majority of rabbits died between 21 and 44 hr after injection following a period of coma which lasted 2.6 hr on average. Serum biochemical tests and liver histology reflected massive hepatic injury. Changes in plasma ammonia and amino acid concentrations, in coagulation parameters, and in the electroencephalogram were similar to those found in human fulminant hepatic failure. This model appears promising for future studies of the pathogenesis and treatment of fulminant hepatic failure.
B L Blitzer, and
J G Waggoner, and
E A Jones, and
H R Gralnick, and
D Towne, and
J Butler, and
V Weise, and
I J Kopin, and
I Walters, and
P F Teychenne, and
D G Goodman, and
P D Berk
January 1983,
Hepatology (Baltimore, Md.),
B L Blitzer, and
J G Waggoner, and
E A Jones, and
H R Gralnick, and
D Towne, and
J Butler, and
V Weise, and
I J Kopin, and
I Walters, and
P F Teychenne, and
D G Goodman, and
P D Berk
February 2012,
World journal of gastroenterology,
B L Blitzer, and
J G Waggoner, and
E A Jones, and
H R Gralnick, and
D Towne, and
J Butler, and
V Weise, and
I J Kopin, and
I Walters, and
P F Teychenne, and
D G Goodman, and
P D Berk
December 2007,
Liver international : official journal of the International Association for the Study of the Liver,
B L Blitzer, and
J G Waggoner, and
E A Jones, and
H R Gralnick, and
D Towne, and
J Butler, and
V Weise, and
I J Kopin, and
I Walters, and
P F Teychenne, and
D G Goodman, and
P D Berk
January 1985,
Journal of hepatology,
B L Blitzer, and
J G Waggoner, and
E A Jones, and
H R Gralnick, and
D Towne, and
J Butler, and
V Weise, and
I J Kopin, and
I Walters, and
P F Teychenne, and
D G Goodman, and
P D Berk
May 2013,
The Journal of surgical research,
B L Blitzer, and
J G Waggoner, and
E A Jones, and
H R Gralnick, and
D Towne, and
J Butler, and
V Weise, and
I J Kopin, and
I Walters, and
P F Teychenne, and
D G Goodman, and
P D Berk
February 2014,
Veterinary research,
B L Blitzer, and
J G Waggoner, and
E A Jones, and
H R Gralnick, and
D Towne, and
J Butler, and
V Weise, and
I J Kopin, and
I Walters, and
P F Teychenne, and
D G Goodman, and
P D Berk
November 1987,
Gastroenterology,
B L Blitzer, and
J G Waggoner, and
E A Jones, and
H R Gralnick, and
D Towne, and
J Butler, and
V Weise, and
I J Kopin, and
I Walters, and
P F Teychenne, and
D G Goodman, and
P D Berk
October 2004,
The Journal of laboratory and clinical medicine,
B L Blitzer, and
J G Waggoner, and
E A Jones, and
H R Gralnick, and
D Towne, and
J Butler, and
V Weise, and
I J Kopin, and
I Walters, and
P F Teychenne, and
D G Goodman, and
P D Berk
February 1989,
Gastroenterology,
B L Blitzer, and
J G Waggoner, and
E A Jones, and
H R Gralnick, and
D Towne, and
J Butler, and
V Weise, and
I J Kopin, and
I Walters, and
P F Teychenne, and
D G Goodman, and
P D Berk
December 1979,
Acta medica Okayama,
