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We have studied the relaxant effect of bovine parathyroid hormone (bPTH) on helical strips of branches of bovine and human middle cerebral arteries and bovine and porcine basilar arteries. All arteries were studied after contraction with prostaglandin (PG) F2 alpha or KCl. In the case of all arteries contracted with PGF2 alpha, the ED50 of PTH vasorelaxation related to maximal vasorelaxation induced by papaverine ranged from 9 to 14 nM for bPTH-(1-34) and 100 to 220 ng/ml for native bPTH-(1-84). The PTH inhibitor, [Nle8, Nle18, Tyr34]bPTH-(3-34) amide, attenuated the vasorelaxant effect of both bPTH-(1-34) and bPTH-(1-84). The vasorelaxant effects of PTH which we have observed in this study are consistent with the stimulatory effects of PTH on vascular adenylate cyclase which we had previously reported.
Y Suzuki, and
K Lederis, and
M Huang, and
F E LeBlanc, and
O P Rorstad
January 1971,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
Y Suzuki, and
K Lederis, and
M Huang, and
F E LeBlanc, and
O P Rorstad
March 1984,
The Journal of biological chemistry,
Y Suzuki, and
K Lederis, and
M Huang, and
F E LeBlanc, and
O P Rorstad
January 1997,
Respiration physiology,
Y Suzuki, and
K Lederis, and
M Huang, and
F E LeBlanc, and
O P Rorstad
January 1991,
Pharmacology,
Y Suzuki, and
K Lederis, and
M Huang, and
F E LeBlanc, and
O P Rorstad
May 1963,
Proceedings of the National Academy of Sciences of the United States of America,
Y Suzuki, and
K Lederis, and
M Huang, and
F E LeBlanc, and
O P Rorstad
July 1988,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
Y Suzuki, and
K Lederis, and
M Huang, and
F E LeBlanc, and
O P Rorstad
March 1979,
The American journal of pathology,
Y Suzuki, and
K Lederis, and
M Huang, and
F E LeBlanc, and
O P Rorstad
September 1967,
Endocrinology,
Y Suzuki, and
K Lederis, and
M Huang, and
F E LeBlanc, and
O P Rorstad
November 1996,
British journal of pharmacology,
Y Suzuki, and
K Lederis, and
M Huang, and
F E LeBlanc, and
O P Rorstad
March 1985,
General and comparative endocrinology,
