-transparent.png){kind=logo}
We have investigated the effects of synthetic oxytocin and vasopressin on corticotropin release induced by the 41-residue ovine corticotropin-releasing factor (oCRF) in vitro. Segments of the anterior pituitary glands obtained from male and female Wistar or from female hetero- and homozygous Brattleboro rats were used. Ovine CRF (0.1-2.5 nmol/l) stimulated corticotropin release by pituitaries of Wistar rats and this effect was augmented two- to threefold in the presence of arginine vasopressin (0.09-0.9 mIU/ml) or oxytocin (0.9-90 mIU/ml). A similar phenomenon was demonstrated in Brattleboro rats. These data favor the hypothesis that oxytocin might have a physiological role in the regulation of pituitary-adrenocortical function in homozygous Brattleboro rats which lack vasopressin.
F A Antoni, and
M C Holmes, and
M T Jones
January 1992,
Experimental and clinical endocrinology,
F A Antoni, and
M C Holmes, and
M T Jones
January 1974,
Neuroendocrinology,
F A Antoni, and
M C Holmes, and
M T Jones
February 1997,
Neuropeptides,
F A Antoni, and
M C Holmes, and
M T Jones
June 1984,
Life sciences,
F A Antoni, and
M C Holmes, and
M T Jones
August 1989,
Archives internationales de physiologie et de biochimie,
F A Antoni, and
M C Holmes, and
M T Jones
December 1986,
Experimental and clinical endocrinology,
F A Antoni, and
M C Holmes, and
M T Jones
January 1988,
Advances in experimental medicine and biology,
F A Antoni, and
M C Holmes, and
M T Jones
April 1990,
The Journal of clinical endocrinology and metabolism,
F A Antoni, and
M C Holmes, and
M T Jones
October 2008,
BMC developmental biology,
F A Antoni, and
M C Holmes, and
M T Jones
January 1990,
Life sciences,
