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Two patients with HBsAg positive chronic active hepatitis have been treated with human fibroblast interferon 10(7) units daily for two weeks. Before treatment, both patients had high levels of hepatitis B surface antigen, core antibody, and DNA-binding antibody in the blood and one patient had a fourfold rise in serum AST. During treatment there was a striking fall in the core antibody titre and also in the DNA-binding antibody, which has been maintained for several months subsequently; in one patient the initially high AST level fell to normal. No significant adverse effects occurred, and these observations should encourage further trials of fibroblasts interferon in hepatitis B.
J G Kingham, and
N K Ganguly, and
Z D Shaari, and
R Mendelson, and
M J McGuire, and
S J Holgate, and
T Cartwright, and
G M Scott, and
B M Richards, and
R Wright
December 1977,
Lancet (London, England),
J G Kingham, and
N K Ganguly, and
Z D Shaari, and
R Mendelson, and
M J McGuire, and
S J Holgate, and
T Cartwright, and
G M Scott, and
B M Richards, and
R Wright
April 1979,
European journal of clinical investigation,
J G Kingham, and
N K Ganguly, and
Z D Shaari, and
R Mendelson, and
M J McGuire, and
S J Holgate, and
T Cartwright, and
G M Scott, and
B M Richards, and
R Wright
January 1984,
Giornale italiano di chemioterapia,
J G Kingham, and
N K Ganguly, and
Z D Shaari, and
R Mendelson, and
M J McGuire, and
S J Holgate, and
T Cartwright, and
G M Scott, and
B M Richards, and
R Wright
January 1980,
Medical microbiology and immunology,
J G Kingham, and
N K Ganguly, and
Z D Shaari, and
R Mendelson, and
M J McGuire, and
S J Holgate, and
T Cartwright, and
G M Scott, and
B M Richards, and
R Wright
January 1982,
Acta gastroenterologica Latinoamericana,
J G Kingham, and
N K Ganguly, and
Z D Shaari, and
R Mendelson, and
M J McGuire, and
S J Holgate, and
T Cartwright, and
G M Scott, and
B M Richards, and
R Wright
July 1981,
The New England journal of medicine,
J G Kingham, and
N K Ganguly, and
Z D Shaari, and
R Mendelson, and
M J McGuire, and
S J Holgate, and
T Cartwright, and
G M Scott, and
B M Richards, and
R Wright
January 1980,
Acta medica Academiae Scientiarum Hungaricae,
J G Kingham, and
N K Ganguly, and
Z D Shaari, and
R Mendelson, and
M J McGuire, and
S J Holgate, and
T Cartwright, and
G M Scott, and
B M Richards, and
R Wright
March 1985,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J G Kingham, and
N K Ganguly, and
Z D Shaari, and
R Mendelson, and
M J McGuire, and
S J Holgate, and
T Cartwright, and
G M Scott, and
B M Richards, and
R Wright
January 1986,
Journal of hepatology,
J G Kingham, and
N K Ganguly, and
Z D Shaari, and
R Mendelson, and
M J McGuire, and
S J Holgate, and
T Cartwright, and
G M Scott, and
B M Richards, and
R Wright
January 1985,
Hepatology (Baltimore, Md.),
