Biomaterial Database

[The oral application of berotec in the therapy of obstructive airway diseases]. 1978

R Veres

The intensity and duration of action of Berotec (fenoterol) syrup in doses of 2.5 mg and 5.0 mg were investigated in an acute cross-over study in comparison with placebo, using the double blind technique. By measurement of the forced expiratory volume (FEV1) and the forced expiratory flow rate (FEF200-1200) significant improvement in pulmonary function could be detected from 1 to 4 hours after administration of 2.5 mg and from 1 to 8 hours after administration fo 5.0 mg Berotec syrup. The intensity of action exhibited a statistically significant dose dependence and was greater after the 5.0 mg dose (p=0.05) than after 2 puffs from Berotec metered aerosol taken by the patients in a pre-test. Minor side effects were observed in 2 cases: in one patient on the 5.0 mg dose they were clearly sympathomimetic and accompanied by a stronger bronchodilating effect.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D001991	Bronchitis	Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.	Bronchitides
D004341	Drug Evaluation	Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.	Evaluation Studies, Drug,Drug Evaluation Studies,Drug Evaluation Study,Drug Evaluations,Evaluation Study, Drug,Evaluation, Drug,Evaluations, Drug,Studies, Drug Evaluation,Study, Drug Evaluation
D004983	Ethanolamines	AMINO ALCOHOLS containing the ETHANOLAMINE; (-NH2CH2CHOH) group and its derivatives.	Aminoethanols
D005260	Female		Females
D005280	Fenoterol	A synthetic adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic.	Berotec,Berotek,Fenoterol Hydrobromide,Fenoterol Hydrochloride,Partusisten,Phenoterol,Th-1165a,p-Hydroxyphenyl-orciprenaline,p-Hydroxyphenylorciprenaline,Hydrochloride, Fenoterol,Th 1165a,Th1165a,p Hydroxyphenyl orciprenaline,p Hydroxyphenylorciprenaline
D005540	Forced Expiratory Flow Rates	The rate of airflow measured during a FORCED VITAL CAPACITY determination.	Expiratory Forced Flow Rates,Flow Rates, Expiratory Forced,Flow Rates, Forced Expiratory
D005541	Forced Expiratory Volume	Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.	Forced Vital Capacity, Timed,Timed Vital Capacity,Vital Capacity, Timed,FEVt,Capacities, Timed Vital,Capacity, Timed Vital,Expiratory Volume, Forced,Expiratory Volumes, Forced,Forced Expiratory Volumes,Timed Vital Capacities,Vital Capacities, Timed,Volume, Forced Expiratory,Volumes, Forced Expiratory
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man