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Forskolin, a drug isolated from the Indian plant Coleus forskohlii, exerts its actions on cells by directly activating the catalytic subunit of adenylatecyclases. The primary effect on heart muscles is the positive inotropic one, at higher forskolin concentrations, an acceleration of the pacemaker activity can be observed. External Ca2+ is required for this augmentation of contraction, verapamil, prenylamine and tetrodotoxin depress these effects. The action of forskolin and digitalis glycosides are to a certain degree additive. Incubation of rat heart slices with forskolin depresses the membrane bound Na+K+-ATPase activity. In smooth muscle cells, forskolin lowers the contractions, evoked by K+, norepinephrine and by angiotensin II. The results are discussed in respect to a forskolin induced enlargement of the Ca2+-uptake of heart muscle cells and a lowering of the Ca2+-sensitivity of the contractile system of smooth muscle cells.
E Lindner, and
H Metzger
February 1986,
Zentralblatt fur Veterinarmedizin. Reihe A,
E Lindner, and
H Metzger
January 1992,
Advances in experimental medicine and biology,
E Lindner, and
H Metzger
January 1974,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
E Lindner, and
H Metzger
September 1984,
The American journal of physiology,
E Lindner, and
H Metzger
February 1989,
European journal of immunology,
E Lindner, and
H Metzger
January 1986,
Drugs under experimental and clinical research,
E Lindner, and
H Metzger
October 1963,
The Journal of physiology,
E Lindner, and
H Metzger
January 1973,
Pharmacology, biochemistry, and behavior,
E Lindner, and
H Metzger
January 1988,
Annals of the New York Academy of Sciences,
E Lindner, and
H Metzger
January 1988,
Neirofiziologiia = Neurophysiology,
