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The effects of furosemide on the mitochondrial electron transport system and on oxidative phosphorylation were explored. Furosemide above the concentration of 2 X 10(-3) mol/l was found to inhibit state 3 (ADP-dependent) respiration of the rat liver, renal cortex, renal medulla mitochondria. State 4 (resting) respiration was not affected by furosemide. Furosemide above the concentration of 7.5 X 10(-6) mol/l (substrate: glutamate-malate), and above 5 X 10(-6) mol/l (substrate: succinate) inhibited the respiration of rat liver mitochondria released by 3,5-di-tert-butyl-4-hydroxybenzylidenemalononitrile (SF 6847). This fact exactly indicates that furosemide inhibits the electron transport system in mitochondria. Furosemide at the concentration of 4 X 10(-3) mol/l inhibited the activities of NADH cytochrome c reductase and succinate cytochrome c reductase in sonicated mitochondrial subparticles of beef heart by 78.2% and 79.2% of control, respectively.
Y Orita, and
Y Fukuhara, and
M Yanase, and
A Ando, and
N Okada, and
H Abe
January 1985,
Annual review of biochemistry,
Y Orita, and
Y Fukuhara, and
M Yanase, and
A Ando, and
N Okada, and
H Abe
April 2020,
Annals of botany,
Y Orita, and
Y Fukuhara, and
M Yanase, and
A Ando, and
N Okada, and
H Abe
October 2020,
Redox biology,
Y Orita, and
Y Fukuhara, and
M Yanase, and
A Ando, and
N Okada, and
H Abe
October 1969,
The Biochemical journal,
Y Orita, and
Y Fukuhara, and
M Yanase, and
A Ando, and
N Okada, and
H Abe
September 1981,
Nihon Jinzo Gakkai shi,
Y Orita, and
Y Fukuhara, and
M Yanase, and
A Ando, and
N Okada, and
H Abe
May 2023,
International journal of molecular sciences,
Y Orita, and
Y Fukuhara, and
M Yanase, and
A Ando, and
N Okada, and
H Abe
August 1985,
Biochemistry international,
Y Orita, and
Y Fukuhara, and
M Yanase, and
A Ando, and
N Okada, and
H Abe
January 2018,
Journal of neuroinfectious diseases,
Y Orita, and
Y Fukuhara, and
M Yanase, and
A Ando, and
N Okada, and
H Abe
October 1980,
Molecular and biochemical parasitology,
Y Orita, and
Y Fukuhara, and
M Yanase, and
A Ando, and
N Okada, and
H Abe
September 1967,
Biochemical and biophysical research communications,
