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Several cephalosporins falsely elevate creatinine concentration as determined by the Jaffé reaction. We studied the in vitro effect of various concentrations of cefoperazone, ceftizoxime, ceftriaxone, ceftazidime, and azthreonam on the creatinine determination in serum, using both a manual and an automated technique. No false elevation or change in baseline creatinine concentration could be observed with any of the five antibiotics. With the use of large concentrations in serum of these beta-lactam antibiotics, we can estimate their lack of interference with creatinine determination in urine as well. Therefore, there is no need to relate the timing of blood (and urine) sampling for creatinine assay to dosage of these antibiotics.
M LeBel, and
R P Paone, and
G P Lewis
January 1980,
Acta clinica Belgica,
M LeBel, and
R P Paone, and
G P Lewis
August 1984,
American journal of clinical pathology,
M LeBel, and
R P Paone, and
G P Lewis
November 2001,
Cellular and molecular life sciences : CMLS,
M LeBel, and
R P Paone, and
G P Lewis
September 1981,
American journal of hospital pharmacy,
M LeBel, and
R P Paone, and
G P Lewis
January 1986,
Reviews of infectious diseases,
M LeBel, and
R P Paone, and
G P Lewis
December 1990,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
M LeBel, and
R P Paone, and
G P Lewis
May 1982,
Fortschritte der Medizin,
M LeBel, and
R P Paone, and
G P Lewis
May 1982,
Il Farmaco; edizione pratica,
M LeBel, and
R P Paone, and
G P Lewis
December 1975,
Helvetica chimica acta,
M LeBel, and
R P Paone, and
G P Lewis
June 2002,
Journal of pharmaceutical and biomedical analysis,
