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The effect of different enzymatic treatments on the specific binding of 3H-Etorphine to the membrane bound opiate receptors from human placenta was studied. Phospholipase A2 inhibited etorphine binding, suggesting either that phospholipids are essential for ligand binding or that products of the phospholipase A2 reaction, either lysophospholipids or fatty acids, disrupt the membrane integrity because of their detergent like properties. Trypsin and alpha-chymotrypsin had no effect, suggesting that the receptors binding site was not accessible to these proteolytic enzymes. We also find that the placental villus upon in vitro stimulation with potassium releases acetylcholine. The inhibitory effect of morphine on acetylcholine release was investigated.
M S Ahmed, and
E E Abdelhamid, and
D Turner
January 1981,
Placenta. Supplement,
M S Ahmed, and
E E Abdelhamid, and
D Turner
January 1983,
Membrane biochemistry,
M S Ahmed, and
E E Abdelhamid, and
D Turner
January 1978,
Advances in biochemical psychopharmacology,
M S Ahmed, and
E E Abdelhamid, and
D Turner
January 1955,
Acta pharmacologica et toxicologica,
M S Ahmed, and
E E Abdelhamid, and
D Turner
February 1986,
Biochemical pharmacology,
M S Ahmed, and
E E Abdelhamid, and
D Turner
March 1974,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
M S Ahmed, and
E E Abdelhamid, and
D Turner
August 1982,
Therapeutische Umschau. Revue therapeutique,
M S Ahmed, and
E E Abdelhamid, and
D Turner
January 1979,
Progress in clinical and biological research,
M S Ahmed, and
E E Abdelhamid, and
D Turner
December 1983,
Nihon Sanka Fujinka Gakkai zasshi,
M S Ahmed, and
E E Abdelhamid, and
D Turner
January 1975,
Annali di ostetricia, ginecologia, medicina perinatale,
