Steroids and idiopathic facial paralysis. 1983

J A Stankiewicz

The face proclaims to the world an individual's identity and as such is the most conspicuous part of his anatomy. No wonder, then, that idiopathic facial paralysis is a frightening experience for the patient. Ever since it was first noted, all manners of measures have been used to bring about early and full recovery. Unfortunately, none of these treatments is effective. Following Rothendler's case description in 1951, a multitude of papers have appeared, evaluating the effectiveness of steroids in idiopathic facial paralysis. This article evaluates 92 of these papers. Only a few properly controlled, randomized prospective studies were available. Their main conclusion was that steroid treatment was not more beneficial than conventional treatment. But several less valid prospective and retrospective studies have suggested that steroid treatment is beneficial. The definitive, statistically valid study of the benefits of steroids in treating has yet to be performed. Until then steroid treatment of this condition will continue to be controversial.

UI MeSH Term Description Entries
D011241 Prednisone A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver. Dehydrocortisone,delta-Cortisone,Apo-Prednisone,Cortan,Cortancyl,Cutason,Dacortin,Decortin,Decortisyl,Deltasone,Encorton,Encortone,Enkortolon,Kortancyl,Liquid Pred,Meticorten,Orasone,Panafcort,Panasol,Predni Tablinen,Prednidib,Predniment,Prednison Acsis,Prednison Galen,Prednison Hexal,Pronisone,Rectodelt,Sone,Sterapred,Ultracorten,Winpred,Acsis, Prednison
D011278 Pregnanes Saturated derivatives of the steroid pregnane. The 5-beta series includes PROGESTERONE and related hormones; the 5-alpha series includes forms generally excreted in the urine.
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D005158 Facial Paralysis Severe or complete loss of facial muscle motor function. This condition may result from central or peripheral lesions. Damage to CNS motor pathways from the cerebral cortex to the facial nuclei in the pons leads to facial weakness that generally spares the forehead muscles. FACIAL NERVE DISEASES generally results in generalized hemifacial weakness. NEUROMUSCULAR JUNCTION DISEASES and MUSCULAR DISEASES may also cause facial paralysis or paresis. Facial Palsy,Hemifacial Paralysis,Facial Palsy, Lower Motor Neuron,Facial Palsy, Upper Motor Neuron,Facial Paralysis, Central,Facial Paralysis, Peripheral,Facial Paresis,Lower Motor Neuron Facial Palsy,Upper Motor Neuron Facial Palsy,Central Facial Paralyses,Central Facial Paralysis,Facial Palsies,Facial Paralyses, Central,Facial Paralyses, Peripheral,Palsies, Facial,Palsy, Facial,Paralyses, Central Facial,Paralyses, Facial,Paralyses, Hemifacial,Paralysis, Central Facial,Paralysis, Facial,Paralysis, Hemifacial,Paralysis, Peripheral Facial,Pareses, Facial,Paresis, Facial,Peripheral Facial Paralysis
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000324 Adrenocorticotropic Hormone An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP). ACTH,Adrenocorticotropin,Corticotropin,1-39 ACTH,ACTH (1-39),Adrenocorticotrophic Hormone,Corticotrophin,Corticotrophin (1-39),Corticotropin (1-39),Hormone, Adrenocorticotrophic,Hormone, Adrenocorticotropic
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective

Related Publications

J A Stankiewicz
September 1998, HNO,
J A Stankiewicz
March 1986, Medicina clinica,
J A Stankiewicz
November 1986, Medicina clinica,
J A Stankiewicz
December 1983, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
J A Stankiewicz
August 1967, Munchener medizinische Wochenschrift (1950),
J A Stankiewicz
January 1987, Zeitschrift fur arztliche Fortbildung,
J A Stankiewicz
May 1966, Monatsschrift fur Ohrenheilkunde und Laryngo-Rhinologie,
J A Stankiewicz
January 1983, Acta neurologica Belgica,
J A Stankiewicz
January 1990, Deutsche medizinische Wochenschrift (1946),
J A Stankiewicz
February 2000, The Journal of laryngology and otology,
Copied contents to your clipboard!