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In female Wistar rats a 10 cm long exteriorized mid small intestinal segment was roentgen irradiated. Nominal standard radiation doses were 17 and 19 Gy, given as a single exposure and in 2 and 3 fractions with intervals of 48 hours. Animals were killed and examined in groups of 3 every 6 weeks from 8 to 44 weeks following irradiation. Macroscopic and histopathologic parameters of irradiation injury were used to calculate an injury score for each animal. In the 2 fractions group both mortality and irradiation injury score were higher than in the single exposure and 3 fractions groups. The difference was due in particular to persisting mucosal ulcerations and epithelial atypia. Adenocarcinoma of the irradiated intestine was found in 4 animals.
M Hauer Jensen, and
T Sauer, and
F Devik, and
K Nygaard
August 1973,
Radiation research,
M Hauer Jensen, and
T Sauer, and
F Devik, and
K Nygaard
June 1988,
International journal of radiation oncology, biology, physics,
M Hauer Jensen, and
T Sauer, and
F Devik, and
K Nygaard
April 1965,
Clinical radiology,
M Hauer Jensen, and
T Sauer, and
F Devik, and
K Nygaard
October 1975,
International journal of radiation biology and related studies in physics, chemistry, and medicine,
M Hauer Jensen, and
T Sauer, and
F Devik, and
K Nygaard
April 1986,
World journal of surgery,
M Hauer Jensen, and
T Sauer, and
F Devik, and
K Nygaard
April 1969,
Langenbecks Archiv fur Chirurgie,
M Hauer Jensen, and
T Sauer, and
F Devik, and
K Nygaard
June 1990,
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
M Hauer Jensen, and
T Sauer, and
F Devik, and
K Nygaard
January 1989,
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
M Hauer Jensen, and
T Sauer, and
F Devik, and
K Nygaard
June 1987,
Meditsinskaia radiologiia,
M Hauer Jensen, and
T Sauer, and
F Devik, and
K Nygaard
January 1998,
Digestion,
