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Acute effects of MK421 were examined in 11 male normal volunteers. Oral administration of 5 mg of MK421 did not induce any changes in blood pressure or pulse rate. Plasma renin activity increased significantly from 7.3 +/- 2.9 ng/ml to 22.2 +/- 7.1 (p less than 0.05), whereas plasma aldosterone concentration did not change. Blood kinin, or urinary excretion of kallikrein and of prostaglandin E did not change. However, urinary excretion of sodium increased significantly from 44.0 +/- 6.8 mEq/4 hr to 56.5 +/- 6.5 (p less than 0.02) following the administration of MK421. The present results show that an increased renin release induced by MK421 is independent of change in blood pressure, and also suggest that MK421 may have a direct action on the renal tubules.
Y Kasai, and
K Abe, and
M Yasujima, and
J Tajima, and
M Seino, and
S Chiba, and
K Sato, and
T Goto, and
K Omata, and
M Tanno
March 1990,
African journal of medicine and medical sciences,
Y Kasai, and
K Abe, and
M Yasujima, and
J Tajima, and
M Seino, and
S Chiba, and
K Sato, and
T Goto, and
K Omata, and
M Tanno
July 1988,
Journal of clinical pharmacology,
Y Kasai, and
K Abe, and
M Yasujima, and
J Tajima, and
M Seino, and
S Chiba, and
K Sato, and
T Goto, and
K Omata, and
M Tanno
October 1994,
Ugeskrift for laeger,
Y Kasai, and
K Abe, and
M Yasujima, and
J Tajima, and
M Seino, and
S Chiba, and
K Sato, and
T Goto, and
K Omata, and
M Tanno
May 1988,
Drug intelligence & clinical pharmacy,
Y Kasai, and
K Abe, and
M Yasujima, and
J Tajima, and
M Seino, and
S Chiba, and
K Sato, and
T Goto, and
K Omata, and
M Tanno
January 1989,
Pharmacotherapy,
Y Kasai, and
K Abe, and
M Yasujima, and
J Tajima, and
M Seino, and
S Chiba, and
K Sato, and
T Goto, and
K Omata, and
M Tanno
October 1986,
Iowa medicine : journal of the Iowa Medical Society,
Y Kasai, and
K Abe, and
M Yasujima, and
J Tajima, and
M Seino, and
S Chiba, and
K Sato, and
T Goto, and
K Omata, and
M Tanno
March 1986,
Drug intelligence & clinical pharmacy,
Y Kasai, and
K Abe, and
M Yasujima, and
J Tajima, and
M Seino, and
S Chiba, and
K Sato, and
T Goto, and
K Omata, and
M Tanno
May 1992,
The American journal of the medical sciences,
Y Kasai, and
K Abe, and
M Yasujima, and
J Tajima, and
M Seino, and
S Chiba, and
K Sato, and
T Goto, and
K Omata, and
M Tanno
January 1984,
Journal of cardiovascular pharmacology,
Y Kasai, and
K Abe, and
M Yasujima, and
J Tajima, and
M Seino, and
S Chiba, and
K Sato, and
T Goto, and
K Omata, and
M Tanno
August 1981,
British medical journal (Clinical research ed.),
