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Morphological differentiation of neuroblastoma cells (NB15) was induced by cAMP effectors in the presence and absence of serine protease inhibitors. In all conditions tested, the percent differentiation was inhibited by protease inhibitors antipain, diisopropylfluorophosphate (DFP), leupeptin, and soybean trypsin inhibitor (SBTI). The level of morphological differentiation obtained in medium containing fetal calf serum was significantly less than the percent differentiation obtained with serum-free medium alone, so serum-free medium was the principal method of induction and comparisons were made to control uninduced cultures or cultures induced with the phosphodiesterase inhibitor R020-1724. Secreted or cell surface caseinolytic protease activity was higher in differentiating cells than in control cultures and was inhibited by the serine protease inhibitors. The effects of the protease inhibitors on growth and differentiation are discussed.
W H Gibson, and
S L Burack, and
A Picciano
January 1996,
Morfologiia (Saint Petersburg, Russia),
W H Gibson, and
S L Burack, and
A Picciano
January 1996,
Biological trace element research,
W H Gibson, and
S L Burack, and
A Picciano
October 1976,
Nature,
W H Gibson, and
S L Burack, and
A Picciano
June 1983,
Cancer research,
W H Gibson, and
S L Burack, and
A Picciano
November 1974,
The Journal of cell biology,
W H Gibson, and
S L Burack, and
A Picciano
November 1975,
Virchows Archiv. B, Cell pathology,
W H Gibson, and
S L Burack, and
A Picciano
January 1991,
Oncology,
W H Gibson, and
S L Burack, and
A Picciano
June 1973,
Proceedings of the National Academy of Sciences of the United States of America,
W H Gibson, and
S L Burack, and
A Picciano
May 1991,
The Journal of steroid biochemistry and molecular biology,
W H Gibson, and
S L Burack, and
A Picciano
July 1999,
Journal of neuroscience research,
