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The present study has been performed to investigate the effect of i.v. administration of taurine on the electrical activity of the epileptogenic focus induced by penicillin applied to the right sensory motor cortex of adult rats. Taurine (100 mg/kg body weight) was administered 15, 30, 60, and 120 min before the application of penicillin. The EEG was unipolarly recorded by means of electrodes applied to the pia. Taurine caused a decrease of the frequency as well as the spike amplitude of epileptic discharge. The spread of epileptogenic foci to the opposite hemisphere was retarded when compared to that of control animals. The maximal antiepileptic effect of taurine was observed when the amino acid was administered 30-60 min previous to penicillin. It is suggested that high concentrations of taurine in the brain might be necessary to inhibit the epileptic activity.
A Alvarez, and
D Marcano de Cotte, and
J R Pérez, and
M A Requena, and
E Vallecalle, and
B D Drujan
April 2012,
Peptides,
A Alvarez, and
D Marcano de Cotte, and
J R Pérez, and
M A Requena, and
E Vallecalle, and
B D Drujan
January 2014,
Acta neurobiologiae experimentalis,
A Alvarez, and
D Marcano de Cotte, and
J R Pérez, and
M A Requena, and
E Vallecalle, and
B D Drujan
September 2013,
Bulletin of experimental biology and medicine,
A Alvarez, and
D Marcano de Cotte, and
J R Pérez, and
M A Requena, and
E Vallecalle, and
B D Drujan
May 1979,
Electroencephalography and clinical neurophysiology,
A Alvarez, and
D Marcano de Cotte, and
J R Pérez, and
M A Requena, and
E Vallecalle, and
B D Drujan
November 1982,
Neurology,
A Alvarez, and
D Marcano de Cotte, and
J R Pérez, and
M A Requena, and
E Vallecalle, and
B D Drujan
December 1960,
Archives of neurology,
A Alvarez, and
D Marcano de Cotte, and
J R Pérez, and
M A Requena, and
E Vallecalle, and
B D Drujan
December 1980,
Experimental neurology,
A Alvarez, and
D Marcano de Cotte, and
J R Pérez, and
M A Requena, and
E Vallecalle, and
B D Drujan
January 2010,
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference,
A Alvarez, and
D Marcano de Cotte, and
J R Pérez, and
M A Requena, and
E Vallecalle, and
B D Drujan
January 1991,
Experimental brain research,
A Alvarez, and
D Marcano de Cotte, and
J R Pérez, and
M A Requena, and
E Vallecalle, and
B D Drujan
October 1976,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
