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In polymorphoneutrophils (PMNs) phagocytosis is accompanied by an increase in peroxidase activity. Accumulation of iodide, thioureylene antithyroid drugs and 17 beta-oestradiol also occurs during the process. There is no evidence of an active iodide transport system in the PMNs as pertechnetate is not concentrated and neither ouabain nor perchlorate abolishes iodide accumulation. The uptakes of 125I, [35S]PTU and [3H]-17 beta-oestradiol were compared in phagocytosing PMNs and the effects of various compounds examined. In addition, chemiluminescence generation from luminol by PMNs and by horseradish peroxidase was studied. This indicated that uptake of all three compounds could be associated with activation of the peroxidase system, and inhibition of this enzyme system caused a reduction in their accumulation.
M M Ferguson, and
W D Alexander, and
J M Connell, and
A G Lappin, and
D C McCruden, and
R MacLure, and
R J Mairs, and
A Younger
June 1979,
Journal of steroid biochemistry,
M M Ferguson, and
W D Alexander, and
J M Connell, and
A G Lappin, and
D C McCruden, and
R MacLure, and
R J Mairs, and
A Younger
July 1977,
Acta endocrinologica,
M M Ferguson, and
W D Alexander, and
J M Connell, and
A G Lappin, and
D C McCruden, and
R MacLure, and
R J Mairs, and
A Younger
December 1979,
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans,
M M Ferguson, and
W D Alexander, and
J M Connell, and
A G Lappin, and
D C McCruden, and
R MacLure, and
R J Mairs, and
A Younger
July 1973,
The Veterinary record,
M M Ferguson, and
W D Alexander, and
J M Connell, and
A G Lappin, and
D C McCruden, and
R MacLure, and
R J Mairs, and
A Younger
January 1983,
Archives of oral biology,
M M Ferguson, and
W D Alexander, and
J M Connell, and
A G Lappin, and
D C McCruden, and
R MacLure, and
R J Mairs, and
A Younger
December 1965,
Steroids,
M M Ferguson, and
W D Alexander, and
J M Connell, and
A G Lappin, and
D C McCruden, and
R MacLure, and
R J Mairs, and
A Younger
January 1986,
Scandinavian journal of urology and nephrology,
M M Ferguson, and
W D Alexander, and
J M Connell, and
A G Lappin, and
D C McCruden, and
R MacLure, and
R J Mairs, and
A Younger
May 1968,
Acta endocrinologica,
M M Ferguson, and
W D Alexander, and
J M Connell, and
A G Lappin, and
D C McCruden, and
R MacLure, and
R J Mairs, and
A Younger
September 1974,
The Journal of obstetrics and gynaecology of the British Commonwealth,
M M Ferguson, and
W D Alexander, and
J M Connell, and
A G Lappin, and
D C McCruden, and
R MacLure, and
R J Mairs, and
A Younger
November 1974,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
