Biomaterial Database

Comparison of the prophylactic use of magnesium trisilicate mixture B.P.C., sodium citrate mixture or cimetidine in obstetrics. 1984

M Frank, and M Evans, and P Flynn, and C Aun

The effects of magnesium trisilicate mixture B.P.C., sodium citrate mixture or cimetidine on gastric pH and aspirated gastric volumes were compared in 78 obstetric patients during elective (a), or emergency (b) surgery. Magnesium trisilicate mixture B.P.C. was associated with the most alkaline values of gastric pH (mean (a) 7.9, (b) 7.3; range 2.9-9.1). Sodium citrate 0.3 mol litre-1 mixture resulted in the narrowest range of pH values of gastric contents (mean (a) 5.4, (b) 5.9; range 3.9-7.7). The ranges of aspirated gastric volumes were wide with both antacid regimens (magnesium trisilicate 12-172 ml, sodium citrate 9-290 ml). Cimetidine increased gastric pH to greater than 2.5 in 82% of patients (mean (a) 6.2, (b) 5.0; range 1.6-7.3), and was associated with significantly smaller volumes of aspirated gastric contents (range 0.5-44 ml). When gastric pH and volume were considered together, the groups of patients who received cimetidine were found to be closest to the defined "safe limits", of pH greater than 2.5 and volume less than 25 ml.

UI	MeSH Term	Description	Entries
D008274	Magnesium	A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
D011015	Pneumonia, Aspiration	A type of lung inflammation resulting from the aspiration of food, liquid, or gastric contents into the upper RESPIRATORY TRACT.	Acid Aspiration Syndrome,Aspiration Pneumonia,Gastric Acid Aspiration Syndrome,Mendelson Syndrome,Mendelson's Syndrome,Acid Aspiration Syndromes,Aspiration Pneumonias,Mendelsons Syndrome,Pneumonias, Aspiration,Syndrome, Acid Aspiration,Syndrome, Mendelson,Syndrome, Mendelson's,Syndromes, Acid Aspiration
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011248	Pregnancy Complications	Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.	Adverse Birth Outcomes,Complications, Pregnancy,Adverse Birth Outcome,Birth Outcome, Adverse,Complication, Pregnancy,Outcome, Adverse Birth,Pregnancy Complication
D011292	Premedication	Preliminary administration of a drug preceding a diagnostic, therapeutic, or surgical procedure. The commonest types of premedication are antibiotics (ANTIBIOTIC PROPHYLAXIS) and anti-anxiety agents. It does not include PREANESTHETIC MEDICATION.	Premedications
D011897	Random Allocation	A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.	Randomization,Allocation, Random
D002927	Cimetidine	A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.	Altramet,Biomet,Biomet400,Cimetidine HCl,Cimetidine Hydrochloride,Eureceptor,Histodil,N-Cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine,SK&F-92334,SKF-92334,Tagamet,HCl, Cimetidine,Hydrochloride, Cimetidine,SK&F 92334,SK&F92334,SKF 92334,SKF92334
D002951	Citrates	Derivatives of CITRIC ACID.
D004630	Emergencies	Situations or conditions requiring immediate intervention to avoid serious adverse results.	Emergency
D005260	Female		Females