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5'-nucleotidase activity, arachidonate metabolism and adenosine uptake were measured in P388 murine leukaemia cells and in a subline resistant to doxorubicin. These membranes related activities were found to be increased in the doxorubicin resistant cell line, compared to the drug sensitive cells. It is suggested that these differences do not play a role in the mechanism of resistance to doxorubicin. Rather they reflect alterations in plasma membrane composition and structure between these cell lines. This study also suggests that the use of decreased 5'-nucleotidase activity as a marker of certain leukaemias should be reviewed with caution. An increase in cell enzyme activity in treated patients may not necessarily indicate a shift toward normal behaviour of these cells, but rather a selection of certain cell subpopulations.
A Ramu, and
D Glaubiger, and
P Soprey, and
G H Reaman, and
N Feuerstein
February 1986,
International journal of cancer,
A Ramu, and
D Glaubiger, and
P Soprey, and
G H Reaman, and
N Feuerstein
January 1992,
Anticancer research,
A Ramu, and
D Glaubiger, and
P Soprey, and
G H Reaman, and
N Feuerstein
May 1988,
Cytometry,
A Ramu, and
D Glaubiger, and
P Soprey, and
G H Reaman, and
N Feuerstein
January 1986,
Cancer chemotherapy and pharmacology,
A Ramu, and
D Glaubiger, and
P Soprey, and
G H Reaman, and
N Feuerstein
October 1984,
British journal of cancer,
A Ramu, and
D Glaubiger, and
P Soprey, and
G H Reaman, and
N Feuerstein
May 1987,
Cell biology international reports,
A Ramu, and
D Glaubiger, and
P Soprey, and
G H Reaman, and
N Feuerstein
January 1983,
Oncology,
A Ramu, and
D Glaubiger, and
P Soprey, and
G H Reaman, and
N Feuerstein
July 2001,
The Journal of pharmacy and pharmacology,
A Ramu, and
D Glaubiger, and
P Soprey, and
G H Reaman, and
N Feuerstein
September 1990,
Biulleten' eksperimental'noi biologii i meditsiny,
A Ramu, and
D Glaubiger, and
P Soprey, and
G H Reaman, and
N Feuerstein
January 1987,
Oncology,
