BIOMAT Database Logo BIOMAT Database Logo

Heavy chain immunoglobulin gene rearrangement in acute nonlymphocytic leukemia. 1984

U Rovigatti, and J Mirro, and G Kitchingman, and G Dahl, and J Ochs, and S Murphy, and S Stass

Samples of leukemic cell DNA from 14 children with acute nonlymphocytic leukemia (ANLL) and 4 human myeloid leukemia cell lines were analyzed for rearrangement in the heavy chain region of the immunoglobulin gene. The diagnosis of ANLL was confirmed in all patients by morphological, cytochemical, and immunologic studies. By restriction endonuclease digestion and hybridization with cloned heavy chain immunoglobulin gene probes for the constant (Cmu) and joining (JH) regions, the DNA of 2 patients and 1 cell line (ML-1) was found to contain rearrangements. The DNA from the remaining 12 patients and 3 cell lines was not rearranged (germline configuration). Both patients with apparent immunoglobulin gene rearrangement achieved complete remission on therapy for ANLL. Immunoglobulin gene rearrangement in phenotypically defined ANLL suggests (1) that such changes may not be limited to lymphoid leukemia of B cell lineage, or (2) that, in some patients, the leukemic transforming event may involve stem cells capable of both B cell and myeloid differentiation.

UI MeSH Term Description Entries
D007143 Immunoglobulin Heavy Chains The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa. Immunoglobulins, Heavy-Chain,Heavy-Chain Immunoglobulins,Ig Heavy Chains,Immunoglobulin Heavy Chain,Immunoglobulin Heavy Chain Subgroup VH-I,Immunoglobulin Heavy Chain Subgroup VH-III,Heavy Chain Immunoglobulins,Heavy Chain, Immunoglobulin,Heavy Chains, Ig,Heavy Chains, Immunoglobulin,Immunoglobulin Heavy Chain Subgroup VH I,Immunoglobulin Heavy Chain Subgroup VH III,Immunoglobulins, Heavy Chain
D007223 Infant A child between 1 and 23 months of age. Infants
D007938 Leukemia A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006) Leucocythaemia,Leucocythemia,Leucocythaemias,Leucocythemias,Leukemias
D009857 Oncogenes Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene. Transforming Genes,Oncogene,Transforming Gene,Gene, Transforming,Genes, Transforming
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D002471 Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill. Neoplastic Transformation, Cell,Neoplastic Cell Transformation,Transformation, Neoplastic Cell,Tumorigenic Transformation,Cell Neoplastic Transformation,Cell Neoplastic Transformations,Cell Transformations, Neoplastic,Neoplastic Cell Transformations,Neoplastic Transformations, Cell,Transformation, Cell Neoplastic,Transformation, Tumorigenic,Transformations, Cell Neoplastic,Transformations, Neoplastic Cell,Transformations, Tumorigenic,Tumorigenic Transformations
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D004262 DNA Restriction Enzymes Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1. Restriction Endonucleases,DNA Restriction Enzyme,Restriction Endonuclease,Endonuclease, Restriction,Endonucleases, Restriction,Enzymes, DNA Restriction,Restriction Enzyme, DNA,Restriction Enzymes, DNA
D006651 Histocytochemistry Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods. Cytochemistry
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

U Rovigatti, and J Mirro, and G Kitchingman, and G Dahl, and J Ochs, and S Murphy, and S Stass
Biallelic heavy chain immunoglobulin gene rearrangement in acute nonlymphocytic leukemia.
April 1986, Blut,
U Rovigatti, and J Mirro, and G Kitchingman, and G Dahl, and J Ochs, and S Murphy, and S Stass
Prognostic significance of immunoglobulin heavy chain gene rearrangement in patients with acute myelogenous leukemia.
June 1997, Leukemia,
U Rovigatti, and J Mirro, and G Kitchingman, and G Dahl, and J Ochs, and S Murphy, and S Stass
Rearrangement of immunoglobulin heavy chain genes in T cell acute lymphoblastic leukemia.
March 1985, Blood,
U Rovigatti, and J Mirro, and G Kitchingman, and G Dahl, and J Ochs, and S Murphy, and S Stass
Heavy-chain immunoglobulin gene rearrangement and cytoplasmic immunoglobulin expression in acute monocytic leukemia following primary germ cell tumor.
February 1995, Annals of hematology,
U Rovigatti, and J Mirro, and G Kitchingman, and G Dahl, and J Ochs, and S Murphy, and S Stass
[Analysis of clonality with immunoglobulin heavy chain gene rearrangement fingerprinting map in childhood acute lymphoblastic leukemia].
January 1997, Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi,
U Rovigatti, and J Mirro, and G Kitchingman, and G Dahl, and J Ochs, and S Murphy, and S Stass
[Hepatitis C and immunoglobulin heavy-chain gene rearrangement].
April 2002, Orvosi hetilap,
U Rovigatti, and J Mirro, and G Kitchingman, and G Dahl, and J Ochs, and S Murphy, and S Stass
Monoclonal immunoglobulin heavy chain gene rearrangement in Fuchs' uveitis.
March 2018, BMC ophthalmology,
U Rovigatti, and J Mirro, and G Kitchingman, and G Dahl, and J Ochs, and S Murphy, and S Stass
Immunoglobulin lambda chain gene rearrangement in a case of acute nonlymphoblastic leukemia.
March 1999, Leukemia,
U Rovigatti, and J Mirro, and G Kitchingman, and G Dahl, and J Ochs, and S Murphy, and S Stass
Immunoglobulin gene rearrangement in acute myelogenous leukemia.
October 1984, Cancer research,
U Rovigatti, and J Mirro, and G Kitchingman, and G Dahl, and J Ochs, and S Murphy, and S Stass
Immunophenotyping and immunoglobulin heavy chain gene rearrangement analysis in cerebrospinal fluid of pediatric patients with acute lymphoblastic leukemia.
May 2009, Leukemia research,
Copied contents to your clipboard!