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The effects of leukotrienes LTD4 and LTB4 on cell proliferation were assessed in a human in vitro lymphocyte transformation assay in the presence of optimal concentrations of PHA, Con A and PWM. Leukotriene D4 and LTB4 (10(-6) to 10(-11) M) did not alter the basal or mitogen-stimulated response. We therefore conclude that these two agents do not play a role in the modulation of human lymphocyte blastogenesis.
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