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Using a human X chromosome-specific DNA library, we have found arbitrary single-copy DNA sequences that reveal useful restriction fragment length polymorphisms. The inheritance of these and other available polymorphic DNA markers has been studied in a series of unrelated three-generation families with large sibships. These families reveal parental phase and allow determination of recombination frequencies by counting recombinant and nonrecombinant chromosomes. The resulting genetic map indicates that the minimal distance from Xp22 to Xqter is 215 recombination units. The spacing of the marker loci is such that the majority of the loci on the X chromosome, including disease loci, will lie within 20 centimorgans of at least one of these loci.
D Drayna, and
K Davies, and
D Hartley, and
J L Mandel, and
G Camerino, and
R Williamson, and
R White
December 1989,
Jinrui idengaku zasshi. The Japanese journal of human genetics,
D Drayna, and
K Davies, and
D Hartley, and
J L Mandel, and
G Camerino, and
R Williamson, and
R White
January 1984,
Human genetics,
D Drayna, and
K Davies, and
D Hartley, and
J L Mandel, and
G Camerino, and
R Williamson, and
R White
October 1987,
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie,
D Drayna, and
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J L Mandel, and
G Camerino, and
R Williamson, and
R White
November 1983,
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik,
D Drayna, and
K Davies, and
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J L Mandel, and
G Camerino, and
R Williamson, and
R White
September 1988,
Genetics,
D Drayna, and
K Davies, and
D Hartley, and
J L Mandel, and
G Camerino, and
R Williamson, and
R White
February 1988,
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie,
D Drayna, and
K Davies, and
D Hartley, and
J L Mandel, and
G Camerino, and
R Williamson, and
R White
April 1988,
BioTechniques,
D Drayna, and
K Davies, and
D Hartley, and
J L Mandel, and
G Camerino, and
R Williamson, and
R White
May 1993,
Oncogene,
D Drayna, and
K Davies, and
D Hartley, and
J L Mandel, and
G Camerino, and
R Williamson, and
R White
January 1986,
Human genetics,
D Drayna, and
K Davies, and
D Hartley, and
J L Mandel, and
G Camerino, and
R Williamson, and
R White
December 1988,
Genetics,
