-transparent.png){kind=logo}
The renin-angiotensin system was studied in eight patients with Cushing's syndrome (four with adrenal adenoma and four with adrenal hyperplasia) and in five normal controls. Basal plasma renin activity (PRA) and aldosterone concentration (PAC) were similar in supine position among Cushing's syndrome due to adrenal adenoma (PRA; 1.0 +/- 0.3 ng/ml/h, PAC; 7.4 +/- 1.0 ng/dl, mean +/- SE), those due to adrenal hyperplasia (1.0 +/- 0.2, 6.9 +/- 0.8) and the controls (0.8 +/- 0.1, 6.4 +/- 0.4). The PRA after furosemide (1 mg/kg i.v.) and 120 min. upright posture stimulation was similar among Cushing's syndrome due to adrenal adenoma (2.2 +/- 0.7 ng/ml/h), those due to adrenal hyperplasia (2.6 +/- 1.7) and the controls (2.5 +/- 1.2). However, the PAC response after the stimulation in Cushing's syndrome due to adrenal hyperplasia (7.1 +/- 1.2 ng/dl) was significantly lower than that in the controls (17.5 +/- 2.1) (p less than 0.01), although there was no significant difference between the PAC response in Cushing's syndrome due to adrenal adenoma (12.6 +/- 1.0) and the controls. These results indicate that PAC response to furosemide and upright pasture stimulation might be suppressed in Cushing's syndrome due to adrenal hyperplasia.
T Baba, and
K Aoyagi, and
S Murabayashi, and
K Sasaki, and
K Nigawara, and
K Takebe
January 1983,
Hormone research,
T Baba, and
K Aoyagi, and
S Murabayashi, and
K Sasaki, and
K Nigawara, and
K Takebe
January 1981,
Endokrynologia Polska,
T Baba, and
K Aoyagi, and
S Murabayashi, and
K Sasaki, and
K Nigawara, and
K Takebe
July 2015,
Zhonghua nei ke za zhi,
T Baba, and
K Aoyagi, and
S Murabayashi, and
K Sasaki, and
K Nigawara, and
K Takebe
January 1978,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
T Baba, and
K Aoyagi, and
S Murabayashi, and
K Sasaki, and
K Nigawara, and
K Takebe
July 1984,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
T Baba, and
K Aoyagi, and
S Murabayashi, and
K Sasaki, and
K Nigawara, and
K Takebe
May 1973,
Nihon Naibunpi Gakkai zasshi,
T Baba, and
K Aoyagi, and
S Murabayashi, and
K Sasaki, and
K Nigawara, and
K Takebe
June 2004,
Nihon rinsho. Japanese journal of clinical medicine,
T Baba, and
K Aoyagi, and
S Murabayashi, and
K Sasaki, and
K Nigawara, and
K Takebe
July 1980,
European journal of clinical pharmacology,
T Baba, and
K Aoyagi, and
S Murabayashi, and
K Sasaki, and
K Nigawara, and
K Takebe
April 2007,
Nihon rinsho. Japanese journal of clinical medicine,
T Baba, and
K Aoyagi, and
S Murabayashi, and
K Sasaki, and
K Nigawara, and
K Takebe
September 2006,
Journal of the renin-angiotensin-aldosterone system : JRAAS,
