Biomaterial Database

Beta-endorphin-, leucine enkephalin- and methionine enkephalin-like immunoreactivity in human cerebrospinal fluid. Simultaneous determination and relation to neurological disorders. 1984

D Neuser, and K P Lesch, and J P Stasch, and H Przuntek

beta-Endorphin, leucine enkephalin and methionine enkephalin, were measured in 41 samples of human lumbar cerebrospinal fluid (CSF) of patients with different neurological diseases. beta-Endorphin-like immunoreactivity (beta-ELI) was present in concentrations between 10 and 150 fmol/ml CSF, and in 30 of the 41 samples studied the levels ranged from 10 to 40 fmol/ml. Methionine enkephalin-like immunoreactivity (MELI) measured 1-85 pmol/ml CSF, with 24 of the 41 samples having values between 3 and 4 pmol/ml. CSF concentrations of leucine enkephalin-like immunoreactivity (LELI) ranged from 0.1 to 12.5 pmol/ml, and in 31 of the 41 CSF samples studied LELI was present in concentrations of 0.1-0.25 pmol/ml. No significant relationship exists between the concentrations of beta-endorphin in CSF and sex and age of patients, CSF protein, CSF IgG and CSF leukocytes. No interrelationship could be found between beta-ELI, MELI and LELI concentrations.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D002493	Central Nervous System Diseases	Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.	CNS Disease,Central Nervous System Disease,Central Nervous System Disorder,CNS Diseases,Central Nervous System Disorders
D004723	Endorphins	One of the three major groups of endogenous opioid peptides. They are large peptides derived from the PRO-OPIOMELANOCORTIN precursor. The known members of this group are alpha-, beta-, and gamma-endorphin. The term endorphin is also sometimes used to refer to all opioid peptides, but the narrower sense is used here; OPIOID PEPTIDES is used for the broader group.	Endorphin
D004743	Enkephalin, Leucine	One of the endogenous pentapeptides with morphine-like activity. It differs from MET-ENKEPHALIN in the LEUCINE at position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.	Leucine Enkephalin,5-Leucine Enkephalin,Leu(5)-Enkephalin,Leu-Enkephalin,5 Leucine Enkephalin,Enkephalin, 5-Leucine,Leu Enkephalin
D004744	Enkephalin, Methionine	One of the endogenous pentapeptides with morphine-like activity. It differs from LEU-ENKEPHALIN by the amino acid METHIONINE in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.	Methionine Enkephalin,5-Methionine Enkephalin,Met(5)-Enkephalin,Met-Enkephalin,5 Methionine Enkephalin,Enkephalin, 5-Methionine,Met Enkephalin
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults