BIOMAT Database Logo BIOMAT Database Logo

Relation between intradental nerve activity and estimated pain in man--a mathematical model. 1984

Uno Fors, and Michael L Ahlquist, and Roger Skagerwall, and Lennart G A Edwall, and Glenn A T Haegerstam
Departments of Endodontics and Biomedical Information, Karolinska Institutet, StockholmSweden.

Intradental nerve activity (INA) induced by cold stimulation of human teeth is regularly accompanied by pain perception. In this study a mathematical model was developed in order to quantify the relationship between INA and pain. In 5 patients (45 experiments) INA was recorded using electrodes implanted in lower incisor teeth. Brief cold stimulations induced bursts of INA. The intensity of the resulting pain was simultaneously evaluated by means of an intermodal matching technique, finger span. The relationship between perceived pain and the integrated INA was analyzed using various mathematical operations (inter alia Fourier analysis) by means of a computer. A transfer function which describes the pain response following INA was found. This preliminary mathematical model, which is characterized by 5 parameters, consists of 2 parts, one which responds to fast changes in the afferent nerve signal, and another which reacts with a delay. The validity of the model has been tested, and it was found that the model consists of an adequate number of parameters and their cross-interaction is low. The analysis indicates that the parameters which determine the pain response following INA can be quantified and that they might be used as a measure of the efficacy of various pain relieving procedures.

UI MeSH Term Description Entries
D008297 Male Males
D008340 Mandibular Nerve A branch of the trigeminal (5th cranial) nerve. The mandibular nerve carries motor fibers to the muscles of mastication and sensory fibers to the teeth and gingivae, the face in the region of the mandible, and parts of the dura. Alveolar Nerve, Inferior,Auriculotemporal Nerve,Buccal Nerve,Deep Temporal Nerve,Lateral Pterygoid Nerve,Masseteric Nerve,Mental Nerve,Mylohyoid Nerve,Auriculotemporal Nerves,Buccal Nerves,Deep Temporal Nerves,Inferior Alveolar Nerve,Inferior Alveolar Nerves,Lateral Pterygoid Nerves,Mandibular Nerves,Masseteric Nerves,Mental Nerves,Mylohyoid Nerves,Nerve, Auriculotemporal,Nerve, Buccal,Nerve, Deep Temporal,Nerve, Inferior Alveolar,Nerve, Lateral Pterygoid,Nerve, Mandibular,Nerve, Masseteric,Nerve, Mental,Nerve, Mylohyoid,Pterygoid Nerve, Lateral,Pterygoid Nerves, Lateral,Temporal Nerve, Deep,Temporal Nerves, Deep
D008433 Mathematics The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Mathematic
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D008959 Models, Neurological Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment. Neurologic Models,Model, Neurological,Neurologic Model,Neurological Model,Neurological Models,Model, Neurologic,Models, Neurologic
D009435 Synaptic Transmission The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES. Neural Transmission,Neurotransmission,Transmission, Neural,Transmission, Synaptic
D010146 Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS. Suffering, Physical,Ache,Pain, Burning,Pain, Crushing,Pain, Migratory,Pain, Radiating,Pain, Splitting,Aches,Burning Pain,Burning Pains,Crushing Pain,Crushing Pains,Migratory Pain,Migratory Pains,Pains, Burning,Pains, Crushing,Pains, Migratory,Pains, Radiating,Pains, Splitting,Physical Suffering,Physical Sufferings,Radiating Pain,Radiating Pains,Splitting Pain,Splitting Pains,Sufferings, Physical
D003080 Cold Temperature An absence of warmth or heat or a temperature notably below an accustomed norm. Cold,Cold Temperatures,Temperature, Cold,Temperatures, Cold
D003782 Dental Pulp A richly vascularized and innervated connective tissue of mesodermal origin, contained in the central cavity of a tooth and delimited by the dentin, and having formative, nutritive, sensory, and protective functions. (Jablonski, Dictionary of Dentistry, 1992) Dental Pulps,Pulp, Dental,Pulps, Dental
D003804 Dentin The hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root, which is harder and denser than bone but softer than enamel, and is thus readily abraded when left unprotected. (From Jablonski, Dictionary of Dentistry, 1992) Dentine,Dentines,Dentins

Related Publications

Uno Fors, and Michael L Ahlquist, and Roger Skagerwall, and Lennart G A Edwall, and Glenn A T Haegerstam
A comparison between different models of the relation between recorded intradental nerve impulse activity and reported pain in man.
March 1989, International journal of bio-medical computing,
Uno Fors, and Michael L Ahlquist, and Roger Skagerwall, and Lennart G A Edwall, and Glenn A T Haegerstam
A new technique for recording of intradental sensory nerve activity in man.
April 1977, Pain,
Uno Fors, and Michael L Ahlquist, and Roger Skagerwall, and Lennart G A Edwall, and Glenn A T Haegerstam
Perception of pulpal pain as a function of intradental nerve activity.
August 1984, Pain,
Uno Fors, and Michael L Ahlquist, and Roger Skagerwall, and Lennart G A Edwall, and Glenn A T Haegerstam
Effect of interstimulus interval on perceived sensation and intradental nerve activity during thermal tooth stimulation in man.
January 1994, Brain research,
Uno Fors, and Michael L Ahlquist, and Roger Skagerwall, and Lennart G A Edwall, and Glenn A T Haegerstam
Role of intradental A- and C-type nerve fibres in dental pain mechanisms.
January 1992, Proceedings of the Finnish Dental Society. Suomen Hammaslaakariseuran toimituksia,
Uno Fors, and Michael L Ahlquist, and Roger Skagerwall, and Lennart G A Edwall, and Glenn A T Haegerstam
Comparison of functional characteristics of intradental A- and C-nerve fibres in dental pain.
March 1996, East African medical journal,
Uno Fors, and Michael L Ahlquist, and Roger Skagerwall, and Lennart G A Edwall, and Glenn A T Haegerstam
Decreasing intradental nerve activity in the cat with potassium and divalent cations.
January 1991, Archives of oral biology,
Uno Fors, and Michael L Ahlquist, and Roger Skagerwall, and Lennart G A Edwall, and Glenn A T Haegerstam
[The relation between sympathetically maintained pain, regional vasomotor disturbances and sympathetic nerve activity: a remaining enigma].
August 1998, Schmerz (Berlin, Germany),
Uno Fors, and Michael L Ahlquist, and Roger Skagerwall, and Lennart G A Edwall, and Glenn A T Haegerstam
Effect of zinc oxide-eugenol and calcium hydroxide on intradental nerve activity.
September 1982, Journal of endodontics,
Uno Fors, and Michael L Ahlquist, and Roger Skagerwall, and Lennart G A Edwall, and Glenn A T Haegerstam
Effects of ammonia and organic acids on the intradental sensory nerve activity.
August 1983, Acta odontologica Scandinavica,
Copied contents to your clipboard!