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This study explores the effects of several divalent metal ions on the in vitro production of cyclic AMP, cyclic GMP, and testosterone by rat testicular tissue and on the amount of binding of [125I]human chorionic gonadotropin (hCG) in the testis. Zn2+ at concentrations of 10(-6) to 10(-4) M enhanced the hCG-stimulated production of cyclic AMP and testosterone, but only in the presence of Ca2+ X [125I]hCG binding to rat testicular tissue was not affected by Zn2+ X Cu2+, Ni2+, Co2+, and Mn2+ did not increase cyclic AMP or testosterone production in concentrations of 10(-7) to 10(-3) M and even inhibited them at a high concentration (10(-2) M). Cyclic GMP production was not affected by these divalent ions. These results suggest that Zn2+ may play an important role in rat testicular steroidogenesis.
Y Nishi, and
S Hatano, and
K Aihara, and
H Okahata, and
H Kawamura, and
K Tanaka, and
Y Miyachi, and
T Usui
November 1974,
Endocrinology,
Y Nishi, and
S Hatano, and
K Aihara, and
H Okahata, and
H Kawamura, and
K Tanaka, and
Y Miyachi, and
T Usui
January 1984,
Life sciences,
Y Nishi, and
S Hatano, and
K Aihara, and
H Okahata, and
H Kawamura, and
K Tanaka, and
Y Miyachi, and
T Usui
March 1981,
Biology of reproduction,
Y Nishi, and
S Hatano, and
K Aihara, and
H Okahata, and
H Kawamura, and
K Tanaka, and
Y Miyachi, and
T Usui
August 1972,
FEBS letters,
Y Nishi, and
S Hatano, and
K Aihara, and
H Okahata, and
H Kawamura, and
K Tanaka, and
Y Miyachi, and
T Usui
June 1985,
Poultry science,
Y Nishi, and
S Hatano, and
K Aihara, and
H Okahata, and
H Kawamura, and
K Tanaka, and
Y Miyachi, and
T Usui
April 1975,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
Y Nishi, and
S Hatano, and
K Aihara, and
H Okahata, and
H Kawamura, and
K Tanaka, and
Y Miyachi, and
T Usui
March 1996,
Research communications in molecular pathology and pharmacology,
Y Nishi, and
S Hatano, and
K Aihara, and
H Okahata, and
H Kawamura, and
K Tanaka, and
Y Miyachi, and
T Usui
January 1987,
Andrologia,
Y Nishi, and
S Hatano, and
K Aihara, and
H Okahata, and
H Kawamura, and
K Tanaka, and
Y Miyachi, and
T Usui
March 1985,
Biochemical and biophysical research communications,
Y Nishi, and
S Hatano, and
K Aihara, and
H Okahata, and
H Kawamura, and
K Tanaka, and
Y Miyachi, and
T Usui
June 1973,
FEBS letters,
