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Lymphadenopathy associated virus ( LAV ) has been isolated from patients with the acquired immunodeficiency syndrome (AIDS) or lymphadenopathy syndrome. Since the immune deficiency in AIDS seems to be primarily related to the defect of the helper-inducer T lymphocyte subset, the possibility that LAV is selectively tropic for this subset was investigated. Fractionation of T lymphocytes was achieved by cellular affinity chromatography with monoclonal antibodies. In a hemophilic patient who was a healthy carrier of LAV , reverse transcriptase activity and virus particles detected by electron microscopy were found only in cultures of helper-inducer lymphocytes. When infected with LAV in vitro, lymphocyte subsets from normal individuals yielded similar results. Virus production was associated with impaired proliferation, modulation of T3-T4 cell markers, and the appearance of cytopathic effects. The results provide evidence for the involvement of LAV in AIDS.
D Klatzmann, and
F Barré-Sinoussi, and
M T Nugeyre, and
C Danquet, and
E Vilmer, and
C Griscelli, and
F Brun-Veziret, and
C Rouzioux, and
J C Gluckman, and
J C Chermann
December 1985,
Transplantation,
D Klatzmann, and
F Barré-Sinoussi, and
M T Nugeyre, and
C Danquet, and
E Vilmer, and
C Griscelli, and
F Brun-Veziret, and
C Rouzioux, and
J C Gluckman, and
J C Chermann
November 1987,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
D Klatzmann, and
F Barré-Sinoussi, and
M T Nugeyre, and
C Danquet, and
E Vilmer, and
C Griscelli, and
F Brun-Veziret, and
C Rouzioux, and
J C Gluckman, and
J C Chermann
January 1986,
Microbiology and immunology,
D Klatzmann, and
F Barré-Sinoussi, and
M T Nugeyre, and
C Danquet, and
E Vilmer, and
C Griscelli, and
F Brun-Veziret, and
C Rouzioux, and
J C Gluckman, and
J C Chermann
June 1987,
The Journal of experimental medicine,
D Klatzmann, and
F Barré-Sinoussi, and
M T Nugeyre, and
C Danquet, and
E Vilmer, and
C Griscelli, and
F Brun-Veziret, and
C Rouzioux, and
J C Gluckman, and
J C Chermann
January 1985,
JAMA,
D Klatzmann, and
F Barré-Sinoussi, and
M T Nugeyre, and
C Danquet, and
E Vilmer, and
C Griscelli, and
F Brun-Veziret, and
C Rouzioux, and
J C Gluckman, and
J C Chermann
May 1992,
The American journal of pathology,
D Klatzmann, and
F Barré-Sinoussi, and
M T Nugeyre, and
C Danquet, and
E Vilmer, and
C Griscelli, and
F Brun-Veziret, and
C Rouzioux, and
J C Gluckman, and
J C Chermann
January 1998,
Industrial health,
D Klatzmann, and
F Barré-Sinoussi, and
M T Nugeyre, and
C Danquet, and
E Vilmer, and
C Griscelli, and
F Brun-Veziret, and
C Rouzioux, and
J C Gluckman, and
J C Chermann
January 1986,
Vox sanguinis,
D Klatzmann, and
F Barré-Sinoussi, and
M T Nugeyre, and
C Danquet, and
E Vilmer, and
C Griscelli, and
F Brun-Veziret, and
C Rouzioux, and
J C Gluckman, and
J C Chermann
July 1986,
Journal of immunology (Baltimore, Md. : 1950),
D Klatzmann, and
F Barré-Sinoussi, and
M T Nugeyre, and
C Danquet, and
E Vilmer, and
C Griscelli, and
F Brun-Veziret, and
C Rouzioux, and
J C Gluckman, and
J C Chermann
January 1985,
Journal of immunological methods,
