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When the human B-lymphoblastoid cell lines GM3299 and GM4408 were heat shocked, elevated levels of antiviral activity were detected. This antiviral activity has been characterized as the result of de novo synthesis of interferon (IFN) gamma. Levels of antiviral activity as high as 20,000 units/ml per 10(6) cells were found after heat treatment. By using anti-IFN-alpha and anti-IFN-gamma sera, it was shown that the high antiviral activity in GM3299 after heat shock is due to a synergistic effect of constitutively produced IFN-alpha and induced IFN-gamma.
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