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Lymphadenopathy-associated virus ( LAV ), a human T- lymphotrophic retrovirus isolated from a homosexual man with lymphadenopathy, has been causally associated with acquired immunodeficiency syndrome (AIDS). A sensitive and specific radioimmunoprecipitation test was developed for the detection of antibodies to the major core protein of LAV , p25 (molecular weight 25,000). Antibody to LAV p25 was found in the serum of 51 of 125 AIDS patients, 81 of 113 patients with lymphadenopathy syndrome, 0 of 70 workers at the Centers for Disease Control (some of whom had handled specimens from AIDS patients), and 0 of 189 random blood donors. Of a group of 100 homosexual men from San Francisco whose serum was obtained in 1978, only one had antibody to LAV p25; in contrast, of a group of 50 homosexual men in the same community whose serum was obtained in 1984, 12 had antibodies to LAV p25.
V S Kalyanaraman, and
C D Cabradilla, and
J P Getchell, and
R Narayanan, and
E H Braff, and
J C Chermann, and
F Barré-Sinoussi, and
L Montagnier, and
T J Spira, and
J Kaplan
January 1985,
JAMA,
V S Kalyanaraman, and
C D Cabradilla, and
J P Getchell, and
R Narayanan, and
E H Braff, and
J C Chermann, and
F Barré-Sinoussi, and
L Montagnier, and
T J Spira, and
J Kaplan
January 1987,
Ophtalmologie : organe de la Societe francaise d'ophtalmologie,
V S Kalyanaraman, and
C D Cabradilla, and
J P Getchell, and
R Narayanan, and
E H Braff, and
J C Chermann, and
F Barré-Sinoussi, and
L Montagnier, and
T J Spira, and
J Kaplan
June 1984,
Lancet (London, England),
V S Kalyanaraman, and
C D Cabradilla, and
J P Getchell, and
R Narayanan, and
E H Braff, and
J C Chermann, and
F Barré-Sinoussi, and
L Montagnier, and
T J Spira, and
J Kaplan
October 1985,
Journal of virological methods,
V S Kalyanaraman, and
C D Cabradilla, and
J P Getchell, and
R Narayanan, and
E H Braff, and
J C Chermann, and
F Barré-Sinoussi, and
L Montagnier, and
T J Spira, and
J Kaplan
October 1984,
Science (New York, N.Y.),
V S Kalyanaraman, and
C D Cabradilla, and
J P Getchell, and
R Narayanan, and
E H Braff, and
J C Chermann, and
F Barré-Sinoussi, and
L Montagnier, and
T J Spira, and
J Kaplan
June 1986,
Tumori,
V S Kalyanaraman, and
C D Cabradilla, and
J P Getchell, and
R Narayanan, and
E H Braff, and
J C Chermann, and
F Barré-Sinoussi, and
L Montagnier, and
T J Spira, and
J Kaplan
March 1985,
The New England journal of medicine,
V S Kalyanaraman, and
C D Cabradilla, and
J P Getchell, and
R Narayanan, and
E H Braff, and
J C Chermann, and
F Barré-Sinoussi, and
L Montagnier, and
T J Spira, and
J Kaplan
January 1986,
AIDS research,
V S Kalyanaraman, and
C D Cabradilla, and
J P Getchell, and
R Narayanan, and
E H Braff, and
J C Chermann, and
F Barré-Sinoussi, and
L Montagnier, and
T J Spira, and
J Kaplan
January 1986,
Microbiology and immunology,
V S Kalyanaraman, and
C D Cabradilla, and
J P Getchell, and
R Narayanan, and
E H Braff, and
J C Chermann, and
F Barré-Sinoussi, and
L Montagnier, and
T J Spira, and
J Kaplan
January 1985,
Vox sanguinis,
