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The alkaline phosphatase isoenzymes in 105 patients with stage D carcinoma of the prostate who entered the National Prostatic Cancer Study were analyzed and these values were correlated to clinical response. Only patients with at least 3 measurements of alkaline phosphatase were evaluated. In 91% of patients with metastatic bone disease, bone alkaline phosphatase was elevated. Those patients with higher pre-treatment levels of alkaline phosphatase generally showed a poorer response to therapy. The results of alkaline phosphatase isoenzyme estimation indicate that these biological markers may be used in the evaluation of patients with metastatic prostatic cancer to predict and monitor their response to chemotherapy. The evaluation of bone and liver alkaline phosphatase isoenzymes in earlier stages also may be valuable.
Z Wajsman, and
T M Chu, and
D Bross, and
J Saroff, and
G P Murphy, and
D E Johnson, and
W W Scott, and
R P Gibbons, and
G R Prout, and
J D Schmidt
August 1976,
Urology,
Z Wajsman, and
T M Chu, and
D Bross, and
J Saroff, and
G P Murphy, and
D E Johnson, and
W W Scott, and
R P Gibbons, and
G R Prout, and
J D Schmidt
October 1974,
Rinsho byori. The Japanese journal of clinical pathology,
Z Wajsman, and
T M Chu, and
D Bross, and
J Saroff, and
G P Murphy, and
D E Johnson, and
W W Scott, and
R P Gibbons, and
G R Prout, and
J D Schmidt
February 1997,
British journal of urology,
Z Wajsman, and
T M Chu, and
D Bross, and
J Saroff, and
G P Murphy, and
D E Johnson, and
W W Scott, and
R P Gibbons, and
G R Prout, and
J D Schmidt
July 1969,
Naika. Internal medicine,
Z Wajsman, and
T M Chu, and
D Bross, and
J Saroff, and
G P Murphy, and
D E Johnson, and
W W Scott, and
R P Gibbons, and
G R Prout, and
J D Schmidt
December 1979,
Journal of clinical pathology,
Z Wajsman, and
T M Chu, and
D Bross, and
J Saroff, and
G P Murphy, and
D E Johnson, and
W W Scott, and
R P Gibbons, and
G R Prout, and
J D Schmidt
July 1981,
Journal of clinical pathology,
Z Wajsman, and
T M Chu, and
D Bross, and
J Saroff, and
G P Murphy, and
D E Johnson, and
W W Scott, and
R P Gibbons, and
G R Prout, and
J D Schmidt
January 1994,
Critical reviews in clinical laboratory sciences,
Z Wajsman, and
T M Chu, and
D Bross, and
J Saroff, and
G P Murphy, and
D E Johnson, and
W W Scott, and
R P Gibbons, and
G R Prout, and
J D Schmidt
October 2000,
Deutsche medizinische Wochenschrift (1946),
Z Wajsman, and
T M Chu, and
D Bross, and
J Saroff, and
G P Murphy, and
D E Johnson, and
W W Scott, and
R P Gibbons, and
G R Prout, and
J D Schmidt
October 1970,
Nihon Ishikai zasshi. Journal of the Japan Medical Association,
Z Wajsman, and
T M Chu, and
D Bross, and
J Saroff, and
G P Murphy, and
D E Johnson, and
W W Scott, and
R P Gibbons, and
G R Prout, and
J D Schmidt
March 1982,
The Journal of urology,
