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Fluorocarbonates are organic compounds capable of carrying oxygen and surrendering it to tissues by means of biological sound modalities. Experimentation of an emulsion consisting of perfluorotripropylamine and perfluorodecaline (Fluosol DA 20%) as a blood substitute is reported. Acute (Ht less than 1%) and chronic morphological (Ht = 15%) studies were performed on rats, and a semi-acute biochemical and morphological protocol (Ht = 21%) was experimented in pigs. The first signs of altered cerebral electrical activity occurred at Ht = 2% in the acute experiments, and death due to respiratory arrest took pace at Ht = 0.5%. In the semiacute and chronic experiments, widespread infiltration of fluorocarbonic micelles was noted on histological and electron microscope lung and liver preparations.
G Motta, and
A Grunert, and
M Herrmann, and
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E Spinelli, and
C Lunghi, and
M Tomellini, and
E Bisio, and
W K Hirlinger, and
M Mayer
January 1983,
The Italian journal of surgical sciences,
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M Mayer
December 1986,
Revue francaise de transfusion et immuno-hematologie,
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A Grunert, and
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W K Hirlinger, and
M Mayer
January 1981,
Problemy gematologii i perelivaniia krovi,
G Motta, and
A Grunert, and
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November 1952,
Klinische Wochenschrift,
G Motta, and
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March 1979,
Revue francaise de transfusion et immuno-hematologie,
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M Mayer
January 1992,
Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology,
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M Mayer
April 1963,
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Journal of the Royal Army Medical Corps,
G Motta, and
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Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen,
