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Fifteen compounds reported to be inhibitors of gelation or sickling were studied by standard methods. These tests included (1) the determination of the solubility of deoxyhemoglobin S or Csat, (2) evaluation of sickling in whole SS blood at various pO2s, (3) measurement of the oxygen affinity of hemoglobin and blood, and (4) examination of red cell indices and morphology. Among the 4 noncovalent agents tested, butylurea was the most potent inhibitor of gelation and sickling in vitro; however, relatively high concentrations were required compared to the covalent agents. In the latter group, bis-(3,5 dibromosalicyl)-fumarate, nitrogen mustard, and dimethyladipimidate were especially effective inhibitors of gelation and/or sickling. All of these compounds require further development before they can be considered for clinical use.
H Chang, and
S M Ewert, and
R M Bookchin, and
R L Nagel
August 1981,
Journal of molecular biology,
H Chang, and
S M Ewert, and
R M Bookchin, and
R L Nagel
January 1981,
Acta haematologica,
H Chang, and
S M Ewert, and
R M Bookchin, and
R L Nagel
January 1984,
The American journal of pediatric hematology/oncology,
H Chang, and
S M Ewert, and
R M Bookchin, and
R L Nagel
October 1973,
Biochemical and biophysical research communications,
H Chang, and
S M Ewert, and
R M Bookchin, and
R L Nagel
March 1975,
Biochemical and biophysical research communications,
H Chang, and
S M Ewert, and
R M Bookchin, and
R L Nagel
April 1975,
Biochemical and biophysical research communications,
H Chang, and
S M Ewert, and
R M Bookchin, and
R L Nagel
January 1985,
Drugs,
H Chang, and
S M Ewert, and
R M Bookchin, and
R L Nagel
March 1983,
The Nursing clinics of North America,
H Chang, and
S M Ewert, and
R M Bookchin, and
R L Nagel
February 1996,
British journal of haematology,
H Chang, and
S M Ewert, and
R M Bookchin, and
R L Nagel
September 1982,
European journal of pharmacology,
