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Effects of intravenous injections of prostaglandin I2 (PG I2) and thromboxane A2 (TXA2) synthetase inhibitor (OKY-1581) on mean arterial pressure (MAP), cardiac output (CO), heart rate (HR), renal blood flow (RBF), and uterine blood flow (UBF) were investigated in the anesthetized pregnant dog. A dose-dependent fall in MAP was observed with these two agents. HR was almost unchanged by both PG I2 and TXA2 synthetase inhibitor. PG I2 and TXA2 synthetase inhibitor produced increases in CO and RBF in a dose-dependent manner. PG I2 caused a dose-dependent decrease in UBF, while TXA2 synthetase inhibitor was followed by an insignificant decrease in UBF. PG I2 and TXA2 synthetase inhibitor did not induce any increase in intrauterine pressure (IUP). The possibility of treatment of pregnancy-induced hypertension with PG I2 or TXA2 synthetase inhibitor is discussed.
K Murayama, and
H Kasai, and
T Adachi, and
O Utsunomiya, and
H Ouchi
February 1981,
European journal of pharmacology,
K Murayama, and
H Kasai, and
T Adachi, and
O Utsunomiya, and
H Ouchi
January 1983,
Advances in prostaglandin, thromboxane, and leukotriene research,
K Murayama, and
H Kasai, and
T Adachi, and
O Utsunomiya, and
H Ouchi
January 1983,
Advances in prostaglandin, thromboxane, and leukotriene research,
K Murayama, and
H Kasai, and
T Adachi, and
O Utsunomiya, and
H Ouchi
September 1983,
Prostaglandins, leukotrienes, and medicine,
K Murayama, and
H Kasai, and
T Adachi, and
O Utsunomiya, and
H Ouchi
October 1991,
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis,
K Murayama, and
H Kasai, and
T Adachi, and
O Utsunomiya, and
H Ouchi
February 1983,
Prostaglandins, leukotrienes, and medicine,
K Murayama, and
H Kasai, and
T Adachi, and
O Utsunomiya, and
H Ouchi
July 1982,
Journal of neurosurgery,
K Murayama, and
H Kasai, and
T Adachi, and
O Utsunomiya, and
H Ouchi
October 1984,
European journal of pharmacology,
K Murayama, and
H Kasai, and
T Adachi, and
O Utsunomiya, and
H Ouchi
January 1997,
Transplantation proceedings,
K Murayama, and
H Kasai, and
T Adachi, and
O Utsunomiya, and
H Ouchi
June 1984,
Acta medica Okayama,
