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4 amebicides (chloroquine diphosphate, diiodohydroxyquin, iodochlorohydroxyquin and dehydroemetine) and 6 anthelmintics (bephenium hydroxynaphthoate, 4-hexylresorcinol, mebendazole, niclosamide, pyrantel pamoate and pyrvinium pamoate) were tested for mutagenicity in the Salmonella typhimurium microsomal test system. Frameshift mutations were induced by dehydroemetine and niclosamide following activation by microsomal enzymes, while pyrvinium pamoate induced both frameshift and base-pair substitution mutations with or without metabolic activation. The urine of mice treated with dehydroemetine or pyrvinium pamoate showed no mutagenic activity. However, urine obtained from mice treated with niclosamide was mutagenic in strains TA98 and TA1538. The fluctuation assay showed chloroquine diphosphate to be mutagenic in TA1537, a strain which detects frameshift mutations.
C Cortinas de Nava, and
J Espinosa, and
L García, and
A M Zapata, and
E Martínez
January 1981,
Environmental mutagenesis,
C Cortinas de Nava, and
J Espinosa, and
L García, and
A M Zapata, and
E Martínez
December 1981,
Mutation research,
C Cortinas de Nava, and
J Espinosa, and
L García, and
A M Zapata, and
E Martínez
October 2020,
Toxicology in vitro : an international journal published in association with BIBRA,
C Cortinas de Nava, and
J Espinosa, and
L García, and
A M Zapata, and
E Martínez
April 1979,
Minerva ginecologica,
C Cortinas de Nava, and
J Espinosa, and
L García, and
A M Zapata, and
E Martínez
December 1979,
Mutation research,
C Cortinas de Nava, and
J Espinosa, and
L García, and
A M Zapata, and
E Martínez
July 1978,
Mutation research,
C Cortinas de Nava, and
J Espinosa, and
L García, and
A M Zapata, and
E Martínez
February 1992,
Mutation research,
C Cortinas de Nava, and
J Espinosa, and
L García, and
A M Zapata, and
E Martínez
January 2000,
The Journal of international medical research,
C Cortinas de Nava, and
J Espinosa, and
L García, and
A M Zapata, and
E Martínez
February 1987,
Mutation research,
C Cortinas de Nava, and
J Espinosa, and
L García, and
A M Zapata, and
E Martínez
March 1999,
Mutagenesis,
