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Hairy cell populations of greater than 90 purity were prepared from six samples obtained from four patients with leukemic reticuloendotheliosis (LRE). These then were analyzed for surface immunoglobulin (SIg) and antigens specified by a panel of monoclonal antibodies. The hairy cells from all patients displayed SIg and antigens reactive with OKIa-1 and OKM-1 antibodies; these markers often were expressed simultaneously. T-cell-specific antigens were not displayed on the surface of hairy cells. The simultaneous expression of SIg and OKM-1 which ordinarily are unique for B cells or myeloid cells, respectively, suggests that hairy cells may represent an aberrant form of either cell type with defective regulation of antigen expression. It alternatively suggests the possibility that B cells and myeloid elements develop along a common pathway and that the hairy cell is a component of such a pathway.
A J Janckila, and
G T Stelzer, and
J H Wallace, and
L T Yam
October 1976,
The New England journal of medicine,
A J Janckila, and
G T Stelzer, and
J H Wallace, and
L T Yam
May 1972,
The American journal of pathology,
A J Janckila, and
G T Stelzer, and
J H Wallace, and
L T Yam
May 1978,
Cancer,
A J Janckila, and
G T Stelzer, and
J H Wallace, and
L T Yam
January 1977,
Nihon rinsho. Japanese journal of clinical medicine,
A J Janckila, and
G T Stelzer, and
J H Wallace, and
L T Yam
December 1977,
The Journal of the Association of Physicians of India,
A J Janckila, and
G T Stelzer, and
J H Wallace, and
L T Yam
January 1977,
Medicinski arhiv,
A J Janckila, and
G T Stelzer, and
J H Wallace, and
L T Yam
March 1979,
Blood,
A J Janckila, and
G T Stelzer, and
J H Wallace, and
L T Yam
January 1977,
The American journal of pathology,
A J Janckila, and
G T Stelzer, and
J H Wallace, and
L T Yam
January 1987,
Archivum immunologiae et therapiae experimentalis,
A J Janckila, and
G T Stelzer, and
J H Wallace, and
L T Yam
January 1978,
Cancer,
